Planta Med 2015; 81 - PO1
DOI: 10.1055/s-0035-1556333

HIV inhibitory activity from Papua New Guinean medicinal plants

CD Pond 1, PP Rai 2, LR Barrows 1, TK Matainaho 2
  • 1Deparment of Pharmacology and Toxicology, University of Utah, 30 S 200E., Salt Lake City, Utah 84112
  • 2School of Medicine and Health Sciences, University of Papua New Guinea, P.O.Box 5623, Boroko, NCD, Papua New Guinea

Papua New Guinea has enormous biological diversity as a result of its topography and tropical latitude. It also has a long and continued use of medicinal plants. In our lab we use bioassay guided discovery and dereplication based on a whole cell HIV assays, p24 flow cytometry, various chromatographic methods, and accurate mass LC/MS/MS. We have explored several collections of medicinal plants gathered by Pharmacy Students under the guidance of UPNG botanists and found several plants with potent anti-HIV activity. Here we report our recent findings on several active plants, including Macaranga Tanarius, Causarina oligodon and Crassocephalum crepidiodes.