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Planta Med 2015; 81 - PK8
DOI: 10.1055/s-0035-1556286
DOI: 10.1055/s-0035-1556286
Discovery of novel bioactive natural product-like compounds based on diversity-enhanced reactions
Diversity-enhanced reaction (DER), a non-selectivity and non-specificity reaction, is proposed to increase the diversified chemical structures of natural products for drug discovery (Fig. 1). We have applied this method to quickly synthesize a number of BB1608-like derivatives (Scheme 1). 2 underwent DER to afford a mixture. Separation and derivatization provided 3 – 12, Compounds 3 – 12 were evaluated for their anticancer and antiviral activities. The development of more complex DER is in progress. [The work described in this paper was supported by HKBU Interdisciplinary Research Matching Scheme (RC-IRMS/12 – 13/03) and Natural Science Foundation of China (No. 21402166)].