Planta Med 2015; 81 - PE10
DOI: 10.1055/s-0035-1556218

Antifungal prenylated isoflavonoids from Maclura aurantiaca

Y Orazbekov 1, 2, 3, U Datkhayev 2, M Omyrzakov 1, 2, AM Metwaly 5, B Makhatov 3, MR Jacob 1, B Ramazanova 2, Z Sakipova 2, A Azembayev 6, K Orazbekuly 7, K Orynbasarova 3, S ARoss 1, 4
  • 1National Center for Natural Products Research,USA
  • 2Department of Pharmacy, Kazakh National Medical University, Almaty, Kazakhstan
  • 3South Kazakhstan pharmaceutical academy, Shymkent, Kazakhstan
  • 4Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
  • 5Department of Pharmacognosy, Faculty of Pharmacy, The University of Al-Azhar, Cairo 11371, Egypt
  • 6Scientific Centre for Anti-infectious Drugs, Kazakhstan
  • 7International Kazakh-Turkish University named after Ahmet Yesevi, Kazakhstan.

Three prenylated isoflavonoids (1 – 3) have been isolated from the ethanolic extract of Maclura aurantiaca fruits. The isolated compounds were chemically identified as 3'-hydroxyeuchrenone (1), euchrenone (2), 5,3',4'-trihydroxy-6-(3-methylbut-2-en-1-yl) isoflavone (3). Compounds 1 and 2 showed antifungal activities against Candida glabrata with IC50 values of 5.7 µg/ml and 1.0 µg/ml, respectively. Compound 3 showed antifungal activities against Cryptococcus neofomans and Candida glabrata with IC50 values of 5.0 µg/ml and 4.9 µg/ml, respectively.