Abstract
The search for indigenous natural antidiabetic and antilipidemec agents is still ongoing.
Medicinal plants are widely used for this purpose. These herbs are very rich sources
of bioactive compounds as flavonoids, polyphenols, tannins, alkaloids which have been
reported as effective role to reduce blood glucose and lipid levels. Securigera securidaca seed is reputed in folk medicine for their value as antidiabetic and antilipidemec
drugs. In this research, the effect of solvent polarity in bioactive extraction contents
of this plant was evaluated by GC-MS analysis. Then antidiabetic and antilipidemic
activies of different extracts were investigated in streptozotocine-induced diabetic
rats and compared to glibenclamide as known chemical drug for diabetes.The results
indicated that, carbon tetrachloride extract of Securigera securidaca seeds showed the best and significant hypoglycemic and hypolipidemic activities compared
to other extracts because of its more sterols and fatty acids content with beta cells
protecting effect from high glucose-induced apoptosis and also increasing in insulin
level and sensitivity.
Key words
solvent polarity -
securigera securidaca seeds - blood glucose and lipid levels - streptozotocine-induced diabetic rats -
sterols and fatty acids