Journal of Pediatric Epilepsy 2015; 04(02): 053-060
DOI: 10.1055/s-0035-1555601
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Single Gene Generalized Epilepsy in Africa

Ashraf Y. Mohamed
1   Department of Molecular Biology, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
,
Ahmed M. Musa
2   Department of Immunology, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
› Author Affiliations
Further Information

Publication History

17 July 2014

28 October 2014

Publication Date:
31 July 2015 (online)

Abstract

The study of families with epilepsy has unraveled several mysteries about the pathophysiology of the disease. However, the majority of those studies were conducted on non-African populations. Africa is strongly believed to be the origin of humans and thus the African genome must give a more comprehensive view of Mendelian diseases. In this review, we have navigated the genes predisposing to familial genetic epilepsies in Africa and compared those to the genes identified worldwide looking for a unique African flavor in familial epilepsies.