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J Pediatr Genet 2015; 04(01): 009-016
DOI: 10.1055/s-0035-1554978
DOI: 10.1055/s-0035-1554978
Review Article
Genetics of Cleft Palate and Velopharyngeal Insufficiency
Further Information
Publication History
12 October 2014
26 December 2014
Publication Date:
17 July 2015 (online)

Abstract
Velopharyngeal insufficiency (VPI) can occur in the setting of an unrepaired or repaired cleft lip and palate. The rate of VPI has been documented as high as 33% in some studies with higher rates of recurrences following surgery associated with genetic syndromes such as 22q11.2 deletions. The primary cause of VPI in these groups is still identified as the anatomic abnormalities of the velum. In this review, the anatomy and physiology of the velum are discussed along with genetic mutations associated with VPI.
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