J Pediatr Infect Dis 2015; 10(01): 022-024
DOI: 10.1055/s-0035-1554966
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Viral Hepatitis with Acute Hemoglobinuria

Jagabandhu Ghosh
1   Department of Paediatrics, I.P.G.M.E.R and S.S.K.M Hospital, Kolkata, West Bengal, India
,
Joydeep Ghosh
2   Department of Biotechnology, Heritage Institute of Technology, Kolkata, West Bengal, India
› Author Affiliations
Further Information

Publication History

28 July 2014

04 December 2014

Publication Date:
03 July 2015 (online)

Abstract

A 7-year-old male child presented with moderate degree fever, yellowish discoloration of eyes and urine. Examination on admission revealed severe anemia, jaundice, hepatomegaly, and splenomegaly. On the day following admission, the child showed evidence of blackish discoloration of urine. The diagnosis was established as viral A hepatitis with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The child recovered with supportive therapy. We suggest that either universal immunization against hepatitis A, or routine newborn screening for G6PD deficiency, could prevent the serious morbidity or mortality that can occur when these two conditions coexist.

Statement Regarding Informed Consent

The parents were informed about the suitability of the case for publication in a medical journal. They gave verbal consent in this regard.


 
  • References

  • 1 Tandon BN, Gandhi BM, Joshi YK. Etiological spectrum of viral hepatitis and prevalence of markers of hepatitis A and B virus infection in north India. Bull World Health Organ 1984; 62 (1) 67-73
  • 2 Beutler E. G6PD deficiency. Blood 1994; 84 (11) 3613-3636
  • 3 Sarkar S, Prakash D, Marwaha RK , et al. Acute intravascular haemolysis in glucose-6-phosphate dehydrogenase deficiency. Ann Trop Paediatr 1993; 13 (4) 391-394
  • 4 Lyons DJ, Gilvarry JM, Fielding JF. Severe haemolysis associated with hepatitis A and normal glucose-6-phosphate dehydrogenase status. Gut 1990; 31 (7) 838-839
  • 5 Tibble JA, Ireland A, Duncan JR. Acute auto immune haemolytic anaemia secondary to hepatitis A infection. Clin Lab Haematol 1997; 19 (1) 73-75
  • 6 Cuthbert JA. Hepatitis A: old and new. Clin Microbiol Rev 2001; 14 (1) 38-58
  • 7 Mishra D, Singh R, Sibal A. Liver transplantation for fulminant hepatitis A infection. Indian Pediatr 2002; 39 (2) 189-192
  • 8 Monga A, Makkar RP, Arora A, Mukhopadhyay S, Gupta AK. Case report: Acute hepatitis E infection with coexistent glucose-6-phosphate dehydrogenase deficiency. Can J Infect Dis Med Microbiol 2003; 14 (4) 230-231
  • 9 Mukerji N. Hemolytic anemia in a patient with G6PD deficiency and acute viral hepatitis. Internet J Hematol 2002; 1 (1) 1
  • 10 Ozbay Hosnut F, Ozcay F, Selda Bayrakci U, Avci Z, Ozbek N. Etiology of hemolysis in two patients with hepatitis A infection: glucose-6-phosphate dehydrogenase deficiency or autoimmune hemolytic anemia. Eur J Pediatr 2008; 167 (12) 1435-1439