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J Neurol Surg Rep 2015; 76(01): e173-e179
DOI: 10.1055/s-0035-1554908
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Intraoperative Extracorporeal Irradiation for the Treatment of the Meningioma-Infiltrated Calvarium

Edward E. Kerr
1   Departments of Neurological Surgery, University of California, Davis School of Medicine, Sacramento, California, United States
,
Ruben Fragoso
2   Departments of Radiation Oncology, University of California, Davis School of Medicine, Sacramento, California, United States
,
Rudolph J. Schrot
1   Departments of Neurological Surgery, University of California, Davis School of Medicine, Sacramento, California, United States
,
Kiarash Shahlaie
1   Departments of Neurological Surgery, University of California, Davis School of Medicine, Sacramento, California, United States
› Author Affiliations
Further Information

Publication History

08 January 2014

09 April 2015

Publication Date:
26 June 2015 (online)

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Abstract

Objectives Complete removal of infiltrated bone is required to achieve a Simpson Grade 1 meningioma resection. Reconstruction of the resulting bone defect is typically achieved with a nonnative implant that can result in poor cosmesis, foreign body reaction, or infection. Extracorporeal irradiation and reimplantation of tumorous bone has been used for limb-sparing surgery with excellent results, but this treatment option is not routinely considered in meningioma surgery. We present a case of anterior fossa meningioma with tumorous overlying calvarium that was successfully managed with intraoperative extracorporeal irradiation and reimplantation.

Design, Setting, and Participant A 37-year-old woman with persistent chronic headaches was found to have an anterior skull base meningioma with extension into the forehead frontal bone. Concurrently with mass resection, the bone flap was irradiated intraoperatively with 120 Gy. After resection of the tumor, the bone flap was replaced in its native position.

Main Outcome Measures and Results Twenty-nine months postoperatively, the patient had an excellent cosmetic outcome with no radiographic evidence of tumor recurrence or significant bone flap resorption.

Conclusion Intraoperative extracorporeal irradiation of tumorous calvaria during meningioma surgery is an effective, logistically feasible treatment option to achieve local tumor control and excellent cosmetic outcome.

Keywords

extracorporeal irradiation - meningioma - tumorous calvarium - skull reconstruction
 

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