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Exp Clin Endocrinol Diabetes 2015; 123(07): 386-393
DOI: 10.1055/s-0035-1554714
DOI: 10.1055/s-0035-1554714
Review
Vitamin D in Thyroid Disorders
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
14. Juli 2015 (online)
Abstract
Vitamin D’s canonical role are its effects exerted on the musculoskeletal system. In the last decades the importance of this hormone has been studied in the context of extraskeletal health. Hypovitaminosis D and several polymorphic variants of genes coding proteins crucial in the transport, metabolism and effects of vitamin D have been associated with negative health outcomes.
In this review the current state of knowledge on the role of vitamin D in thyroid disorders is presented. The review is based on a literature search of the PubMed database performed in December 2014. The following search terms were used in conjunction with ‘vitamin D’: thyroid cancer, Graves’, Hashimoto, thyroiditis, autoimmune thyroid, AITD, nodules, hyperthyroidism, and hypothyroidism.
Currently, similarly to other extraskeletal health outcomes, a clear role of vitamin D has not been demonstrated in thyroid disorders. Further research is necessary to fully elucidate the importance of vitamin D in case of thyroid disease.
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References
- 1 Abd El Gawad SS, Abdul Samee ER, Metwali AA et al. Vitamin D receptor gene polymorphism and its association with 1,25-dihydroxyvitamin D(3) in patients with Graves disease in an Egyptian population: a pilot study. Endocr Pract 2012; 18.2: 132-139
- 2 Autier P, Boniol M, Pizot C et al. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol 2014; 2.1: 76-89
- 3 Balla B, Tobias B, Kosa JP et al. Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer. J Endocrinol Invest. 2014
- 4 Ban Y, Taniyama M, Ban Y. Vitamin D receptor gene polymorphisms in Hashimoto’s thyroiditis. Thyroid 2001; 11.6: 607-608
- 5 Bikle DD. Vitamin D and cancer: the promise not yet fulfilled. Endocrine 2014; 46.1: 29-38
- 6 Bizhanova A, Kopp P. Controversies concerning the role of pendrin as an apical iodide transporter in thyroid follicular cells. Cellular Physiology And Biochemistry: International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2011; 28.3: 485-490
- 7 Bizzaro G, Shoenfeld Y. Vitamin D and thyroid autoimmune diseases: the known and the obscure. Immunol Res 2015; 61.1-2: 107-109
- 8 Bouillon R. Vitamin D and extraskeletal health. UpToDate October 29, 2014 2014. Web. December 4 2014
- 9 Bouillon R, Muls E, De Moor P. Influence of thyroid function on the serum concentration of 1,25-dihydroxyvitamin D3. J Clin Endocrinol Metab 1980; 51.4: 793-797
- 10 Bozkurt NC, Karbek B, Ucan B et al. The association between severity of vitamin D deficiency and Hashimoto’s thyroiditis. Endocr Pract 2013; 19.3: 479-484
- 11 Camurdan OM, Doger E, Bideci A et al. Vitamin D status in children with Hashimoto thyroiditis. J Pediatr Endocrinol Metab 2012; 25.5-6: 467-470
- 12 Chailurkit LO, Aekplakorn W, Ongphiphadhanakul B. High vitamin D status in younger individuals is associated with low circulating thyrotropin. Thyroid 2013; 23.1: 25-30
- 13 Chailurkit LO, Aekplakorn W, Ongphiphadhanakul B. High vitamin D status in younger individuals is associated with low circulating thyrotropin. Thyroid: Official Journal Of The American Thyroid Association 2013; 23.1: 25-30
- 14 Chen W, Lin H, Wang M. Immune intervention effects on the induction of experimental autoimmune thyroiditis. J Huazhong Univ Sci Technolog Med Sci 2002; 22.4: 343-345 354
- 15 Choi YM, Kim WG, Kim TY et al. Low levels of serum vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women. Thyroid 2014; 24.4: 655-661
- 16 Clinckspoor I, Hauben E, Verlinden L et al. Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors. J Histochem Cytochem 2012; 60.7: 502-511
- 17 Clinckspoor I, Verlinden L, Mathieu C et al. Vitamin D in thyroid tumorigenesis and development. Prog Histochem Cytochem 2013; 48.2: 65-98
- 18 Clinckspoor I, Verlinden L, Overbergh L et al. 1,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer. J Steroid Biochem Mol Biol 2011; 124.1-2: 1-9
- 19 D’Aurizio F, Villalta D, Metus P et al. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases?. Autoimmun Rev 2014;
- 20 Demir K, Keskin M, Kor Y et al. Autoimmune thyroiditis in children and adolescents with type 1 diabetes mellitus is associated with elevated IgG4 but not with low vitamin D. Hormones (Athens) 2014; 13.3: 361-368
- 21 Effraimidis G, Badenhoop K, Tijssen JG et al. Vitamin D deficiency is not associated with early stages of thyroid autoimmunity. Eur J Endocrinol 2012; 167.1: 43-48
- 22 Effraimidis G, Wiersinga WM. Mechanisms in endocrinology: autoimmune thyroid disease: old and new players. Eur J Endocrinol 2014; 170.6: R241-R252
- 23 Feng M, Li H, Chen SF et al. Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Endocrine 2013; 43.2: 318-326
- 24 Fournier C, Gepner P, Sadouk M et al. In vivo beneficial effects of cyclosporin A and 1,25-dihydroxyvitamin D3 on the induction of experimental autoimmune thyroiditis. Clin Immunol Immunopathol 1990; 54.1: 53-63
- 25 Goswami R, Marwaha RK, Gupta N et al. Prevalence of vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: a community-based survey. Br J Nutr 2009; 102.3: 382-386
- 26 Grant WB. Ecological studies of the UVB-vitamin D-cancer hypothesis. Anticancer Res 2012; 32.1: 223-236
- 27 Grant WB. Hypothesis – ultraviolet-B irradiance and vitamin D reduce the risk of viral infections and thus their sequelae, including autoimmune diseases and some cancers. Photochem Photobiol 2008; 84.2: 356-365
- 28 Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357.3: 266-281
- 29 Inoue N, Watanabe M, Ishido N et al. The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases. Clin Exp Immunol 2014; 178.2: 262-269
- 30 Jastrup B, Mosekilde L, Melsen F et al. Serum levels of vitamin D metabolites and bone remodelling in hyperthyroidism. Metabolism 1982; 31.2: 126-132
- 31 Jones G. Extrarenal vitamin D activation and interactions between vitamin D(2), vitamin D(3), and vitamin D analogs. Annu Rev Nutr 2013; 33: 23-44
- 32 Jonklaas J, Danielsen M, Wang H. A pilot study of serum selenium, vitamin D, and thyrotropin concentrations in patients with thyroid cancer. Thyroid 2013; 23.9: 1079-1086
- 33 Kawakami-Tani T, Fukawa E, Tanaka H et al. Effect of 1 alpha-hydroxyvitamin D3 on serum levels of thyroid hormones in hyperthyroid patients with untreated Graves’ disease. Metabolism 1997; 46.10: 1184-1188
- 34 Khadzkou K, Buchwald P, Westin G et al. 25-hydroxyvitamin D3 1alpha-hydroxylase and vitamin D receptor expression in papillary thyroid carcinoma. J Histochem Cytochem 2006; 54.3: 355-361
- 35 Kim JR, Kim BH, Kim SM et al. Low serum 25 hydroxyvitamin d is associated with poor clinicopathologic characteristics in female patients with papillary thyroid cancer. Thyroid 2014; 24.11: 1618-1624
- 36 Kivity S, Agmon-Levin N, Zisappl M et al. Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol 2011; 8.3: 243-247
- 37 Krysiak R, Kowalska B, Okopien B. Serum 25-Hydroxyvitamin D and parathyroid hormone levels in non-lactating women with postpartum thyroiditis: The effect of L-Thyroxine treatment. Basic Clin Pharmacol Toxicol 2014;
- 38 Kurylowicz A, Badenhoop K. CYP27B1 gene polymorphism is associated with Graves’ disease in a Polish population study. Thyroid 2005; 15.9: 1107-1108
- 39 Kurylowicz A, Ramos-Lopez E, Bednarczuk T et al. Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves’ disease and the vitamin D status in a Polish population study. Exp Clin Endocrinol Diabetes 2006; 114.6: 329-335
- 40 Laney N, Meza J, Lyden E et al. The Prevalence of Vitamin D Deficiency Is Similar between Thyroid Nodule and Thyroid Cancer Patients. Int J Endocrinol 2010; 2010: 805716
- 41 Lin WY, Wan L, Tsai CH et al. Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto’s thyroiditis in Chinese patients in Taiwan. J Clin Lab Anal 2006; 20.3: 109-112
- 42 Liu S, Xiong F, Liu EM et al. Effects of 1,25-dihydroxyvitamin D3 in rats with experimental autoimmune thyroiditis. Nan Fang Yi Ke Da Xue Xue Bao 2010; 30.7: 1573-1576
- 43 Liu W, Asa SL, Fantus IG et al. Vitamin D Arrests Thyroid Carcinoma Cell Growth and Induces p27 Dephosphorylation and Accumulation through PTEN/Akt-Dependent and -Independent Pathways. Am J Pathol 2002; 160.2: 511-519
- 44 Lizis-Kolus K, Hubalewska-Dydejczyk A, Trofimiuk-Muldnerz M et al. Assessment of 25(OH)D3, concentration levels in patients with papillary thyroid cancer compared to patients with Hashimoto’s thyroiditis. Przegl Lek 2013; 70.11: 920-925
- 45 Lopez ER, Zwermann O, Segni M et al. A promoter polymorphism of the CYP27B1 gene is associated with Addison’s disease, Hashimoto’s thyroiditis, Graves’ disease and type 1 diabetes mellitus in Germans. Eur J Endocrinol 2004; 151.2: 193-197
- 46 MacFarlane IA, Mawer EB, Berry J et al. Vitamin D metabolism in hyperthyroidism. Clin Endocrinol (Oxf) 1982; 17.1: 51-59
- 47 Mackawy AM, Al-Ayed BM, Al-Rashidi BM. Vitamin d deficiency and its association with thyroid disease. Int J Health Sci (Qassim) 2013; 7.3: 267-275
- 48 Mansournia N, Mansournia MA, Saeedi S et al. The association between serum 25OHD levels and hypothyroid Hashimoto’s thyroiditis. J Endocrinol Invest 2014; 37.5: 473-476
- 49 Morand GB, da Silva SD, Hier MP et al. Insights into Genetic and Epigenetic Determinants with Impact on Vitamin D Signaling and Cancer Association Studies: The Case of Thyroid Cancer. Front Oncol 2014; 4: 309
- 50 Muscogiuri G, Mitri J, Mathieu C et al. Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease. Eur J Endocrinol 2014; 171.3: R101-R110
- 51 Pani MA, Regulla K, Segni M et al. A polymorphism within the vitamin D-binding protein gene is associated with Graves’ disease but not with Hashimoto’s thyroiditis. The Journal Of Clinical Endocrinology And Metabolism 2002; 87.6: 2564-2567
- 52 Pani MA, Regulla K, Segni M et al. Vitamin D 1alpha-hydroxylase (CYP1alpha) polymorphism in Graves’ disease, Hashimoto’s thyroiditis and type 1 diabetes mellitus. European Journal Of Endocrinology/European Federation Of Endocrine Societies 2002; 146.6: 777-781
- 53 Penna-Martinez M, Ramos-Lopez E, Stern J et al. Vitamin D receptor polymorphisms in differentiated thyroid carcinoma. Thyroid 2009; 19.6: 623-628
- 54 Penna-Martinez M, Ramos-Lopez E, Stern J et al. Impaired vitamin D activation and association with CYP24A1 haplotypes in differentiated thyroid carcinoma. Thyroid 2012; 22.7: 709-716
- 55 Pludowski P, Holick MF, Pilz S et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality – a review of recent evidence. Autoimmun Rev 2013; 12.10: 976-989
- 56 Prietl B, Treiber G, Pieber TR et al. Vitamin D and immune function. Nutrients 2013; 5.7: 2502-2521
- 57 Roskies M, Dolev Y, Caglar D et al. Vitamin D deficiency as a potentially modifiable risk factor for thyroid cancer. J. Otolaryngol Head Neck Surg 2012; 41.3: 160-163
- 58 Ross DS. Thyroid hormone synthesis and physiology. UpToDate. 2015 Web
- 59 Rotondi M, Chiovato L. Vitamin D deficiency in patients with Graves’ disease: probably something more than a casual association. Endocrine 2013; 43.1: 3-5
- 60 Sahin M, Ucan B, Ginis Z et al. Vitamin D3 levels and insulin resistance in papillary thyroid cancer patients. Med Oncol 2013; 30.2: 589
- 61 Schottker B, Haug U, Schomburg L et al. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J Clin Nutr 2013; 97.4: 782-793
- 62 Sharma V, Fretwell D, Crees Z et al. Thyroid cancer resistance to vitamin D receptor activation is associated with 24-hydroxylase levels but not the ff FokI polymorphism. Thyroid 2010; 20.10: 1103-1111
- 63 Shin DY, Kim KJ, Kim D et al. Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei Med J 2014; 55.2: 476-481
- 64 Speeckaert M, Huang G, Delanghe JR et al. Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta 2006; 372.1-2: 33-42
- 65 Stefanic M, Karner I, Glavas-Obrovac L et al. Association of vitamin D receptor gene polymorphism with susceptibility to Graves’ disease in Eastern Croatian population: case-control study. Croat Med J 2005; 46.4: 639-646
- 66 Stepien T, Krupinski R, Sopinski J et al. Decreased 1-25 dihydroxyvitamin D3 concentration in peripheral blood serum of patients with thyroid cancer. Arch Med Res 2010; 41.3: 190-194
- 67 Stocklin E, Eggersdorfer M. Vitamin D, an essential nutrient with versatile functions in nearly all organs. Int J Vitam Nutr Res 2013; 83.2: 92-100
- 68 Szczeklik A, Augustynowicz-Kopeć E. Choroby wewnętrzne: stan wiedzy na rok 2011. Kraków: Medycyna Praktyczna; 2011. 2011
- 69 Theodoratou E, Tzoulaki I, Zgaga L et al. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ 2014; 348: g2035
- 70 Unal AD, Tarcin O, Demirag NG et al. Vitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis. Central European Journal of Immunology 2014; 39.4: 493-497
- 71 Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermatoendocrinol 2013; 5.1: 51-108
- 72 Xu Y, He B, Pan Y et al. Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Tumour Biol 2014; 35.5: 4153-4169
- 73 Yasuda T, Okamoto Y, Hamada N et al. Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves’ disease. Endocrine 2012; 42.3: 739-741
- 74 Yasuda T, Okamoto Y, Hamada N et al. Serum vitamin D levels are decreased in patients without remission of Graves’ disease. Endocrine 2013; 43.1: 230-232
- 75 Yazici D, Yavuz D, Tarcin O et al. Vitamin D receptor gene ApaI, TaqI, FokI and BsmI polymorphisms in a group of Turkish patients with Hashimoto’s thyroiditis. Minerva Endocrinol 2013; 38.2: 195-201
- 76 Yin K, Agrawal DK. Vitamin D and inflammatory diseases. Journal Of Inflammation Research 2014; 7: 69-87
- 77 Zhang H, Liang L, Xie Z. Low vitamin D status is associated with increased titers of thyroid stimulating hormone receptor antibodies in Graves’ disease. Endocr Pract 2014; 1-23
- 78 Zhang LR, Sawka AM, Adams L et al. Vitamin and mineral supplements and thyroid cancer: a systematic review. Eur J Cancer Prev 2013; 22.2: 158-168
- 79 Zhang Q, Wang Z, Sun M et al. Association of high vitamin D status with low circulating thyroid-stimulating hormone independent of thyroid hormone levels in middle-aged and elderly males. Int J Endocrinol 2014; Epub 2014 Feb : -
- 80 Zhou H, Xu C, Gu M. Vitamin D receptor (VDR) gene polymorphisms and Graves’ disease: a meta-analysis. Clin Endocrinol (Oxf) 2009; 70.6: 938-945
- 81 Zou M, BinHumaid FS, Alzahrani AS et al. Increased CYP24A1 expression is associated with BRAF(V600E) mutation and advanced stages in papillary thyroid carcinoma. Clin Endocrinol (Oxf) 2014; 81.1: 109-116