Diabetologie und Stoffwechsel 2015; 10 - P293
DOI: 10.1055/s-0035-1549799

Influence of lifestyle-induced weight loss on bile acids, FGF19 and total GLP1 in individuals with metabolic syndrome

R Biemann 1, M Penner 1, K Biemann 1, HU Marschall 2, K Borucki 1, S Westphal 1, C Luley 1, J Schneider 3, B Isermann 1
  • 1Institute for Clinical Chemistry and Pathobiochemistry; Otto-von-Guericke University, Magdeburg, Germany
  • 2Sahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
  • 3Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg, Luxembourg

Introduction: Bile acids (BAs) were identified as powerful metabolic regulators and discussed to influence development of the metabolic syndrome (MetS). Moreover, the secretion of FGF19 and GLP1 is controlled by BA receptors TGR5 and FXR suggesting a feedback mechanism between BA homeostasis and metabolism. Hence, we investigated the relationship between individual endogenous BA levels and the metabolic parameters FGF19 and GLP1 following lifestyle-induced weight loss in individuals with MetS by a longitudinal study.

Methods: 74 non-smoking men (45 – 55 yr) with MetS have been randomized to a telemonitored lifestyle-induced weight loss program (ABC-Program: reduced caloric intake and enhanced physical activity) or a control group. Before and after the 6 month intervention period, serum BA profile as well as concentrations of FGF19 and GLP1 were determined. Relative Cyp27a1 expression was quantified in adipose tissue.

Results: Weight loss resulted in a decline of primary BA fractions CDCA and CA as well as secondary BA fraction UDCA. BA pool composition changed specifically with an increase of 12-alpha-hydroxylated BAs over non-12-alpha-hydroxylated BAs. Interestingly, no individual BA was increased during lifestyle-induced weight loss. While total GLP1 concentration decreased, the circulating levels of FGF19 remained stable. Relative expression of Cyp27a1 was reduced after lifestyle-induced weight loss.

Conclusion: Our results suggest that lifestyle-induced weight loss and recovered metabolic control is associated with lower plasma levels of BAs and GLP1 as well as reduced relative expression of Cyp27a1 in adipose tissue. These results may provide new insight in pathophysiology of MetS.