Membrane Stress in the Human Labyrinth and Meniere Disease: A Model Analysis
04 February 2015
21 February 2015
07 April 2015 (online)
Introduction The nature and extent of membrane damage encountered in Meniere disease remains unexplained. Pressure-induced membrane stress may underlie the characteristic hydropic distention. Analysis of stress in the several vestibular chambers may offer insight into the nature and progression of Meniere disease.
Objective Membrane stress levels will be assessed by constructing a specific model of the human membranous labyrinth through the application of human dimensions to an existing generic model of the mammalian labyrinth.
Methods Nominal dimensions for a model of the human membranous labyrinth were obtained from fixed human tissue. Stress proclivities were calculated and normalized based on shell theory applied to the various geometric figures comprising the model.
Results Normalized peak stress levels were projected to be highest in the saccule (38.8), followed by the utricle (5.4), then ampulla (2.4), and lowest in the canal system (1.0). These results reflect macrostructural variations in membrane shape, size, and thickness among the several chambers of the labyrinth. These decreasing stress proclivities parallel the decreasing frequency of histologic lesions found in documented cases of Meniere disease.
Conclusions This model analysis of a human membranous labyrinth indicates that substantial disparities in stress exist among the several vestibular chambers due to macrostructural membrane configuration. Low stress levels in the canals are the result of thick highly curved membranes, and the high levels computed for the saccule reflect its thin and relatively flat membranes. These findings suggest that chamber configuration may be a factor controlling the progression of endolymphatic hydrops in Meniere disease.
- 1 Cotugno D. De Aquaeductibus Auris Humanae Internae. Neapoli et Bononiae: Ex Typographia Sancti Thomae Aquinatis; 1775
- 2 Scarpa A. Anatomische Untersuchungen des Gehors und Geruchs. Nürnberg: Raspe; 1797: 76-85
- 3 Schuknecht HF, Benitez JT, Beekhuis J. Further observations on the pathology of Meniere's disease. Ann Otol Rhinol Laryngol 1962; 71: 1039-1053
- 4 Kimura RS. Distribution, structure, and function of dark cells in the vestibular labyrinth. Ann Otol Rhinol Laryngol 1969; 78 (3) 542-561
- 5 Perlman HB. The saccule: observations on a differentiated re-enforced area of the saccular wall in man. Arch Otolaryngol 1940; 32: 678-691
- 6 Hallpike CS, Cairns H. Observations on the pathology of Ménière's syndrome: (Section of Otology). Proc R Soc Med 1938; 31 (11) 1317-1336
- 7 Ito S, Fisch U, Dillier N, Pollak A. Endolymphatic pressure in experimental hydrops. Arch Otolaryngol Head Neck Surg 1987; 113 (8) 833-835
- 8 EFUNDA. Engineering Fundamentals: Thin walled pressure vessels. 2006; Available at: http://www.efunda.com
- 9 Fung YC. Biomechanics: Mechanical Properties of Living Tissues. New York, NY: Springer-Verlag; 1993
- 10 Shigley JE, Mischke CR, Budynas RG. Mechanical Engineering Design. New York, NY: McGraw-Hill; 2004
- 11 Pender DJ. A model analysis of static stress in the vestibular membranes. Theor Biol Med Model 2009; 6: 19
- 12 Pender DJ. A model design for the labyrinthine membranes in mammals. Laryngoscope 2014; 124 (6) E245-E249
- 13 Pender DJ. Membrane stress proclivities in the mammalian labyrinth. Int Arch Otorhinolaryngol 2014; 18: 398-402
- 14 Curthoys IS, Oman CM. Dimensions of the horizontal semicircular duct, ampulla and utricle in the human. Acta Otolaryngol 1987; 103 (4) 254-261
- 15 Box GEP. Robustness in the strategy of scientific model building. In: Launer RL, Wilkinson GN, , eds. Robustness in Statistics. New York, NY: Academic Press; 1979
- 16 Pender DJ. A model analysis of tensile stress in the toadfish vestibular membranes. Int J Otolaryngol 2011; 2011: 519293
- 17 Macura KJ, Corl FM, Fishman EK, Bluemke DA. Pathogenesis in acute aortic syndromes: aortic aneurysm leak and rupture and traumatic aortic transection. Am J Roentgenol 2003; 181 (2) 303-307
- 18 Shubert HD. Anatomy of the orbit. 2006;
- 19 Kuraku S, Kuratani S. Time scale for cyclostome evolution inferred with a phylogenetic diagnosis of hagfish and lamprey cDNA sequences. Zoolog Sci 2006; 23 (12) 1053-1064
- 20 Baek S, Rajagopal KR, Humphrey JD. A theoretical model of enlarging intracranial fusiform aneurysms. J Biomech Eng 2006; 128 (1) 142-149
- 21 Pender DJ. Endolymphatic hydrops and Ménière's disease: a lesion meta-analysis. J Laryngol Otol 2014; 128 (10) 859-865
- 22 Morita N, Kariya S, Farajzadeh Deroee A , et al. Membranous labyrinth volumes in normal ears and Ménière disease: a three-dimensional reconstruction study. Laryngoscope 2009; 119 (11) 2216-2220
- 23 Sperling NM, Paparella MM, Yoon TH, Zelterman D. Symptomatic versus asymptomatic endolymphatic hydrops: a histopathologic comparison. Laryngoscope 1993; 103 (3) 277-285
- 24 Shinozaki N, Kimura RS. Scanning electron microscopic observations on the distended Reissner's and saccular membranes in the guinea pig. Acta Otolaryngol 1980; 90 (5-6) 370-384