Exp Clin Endocrinol Diabetes 2015; 123 - LB_12
DOI: 10.1055/s-0035-1549078

Differences in polysomnography between patients suffering from Conn's syndrome in comparison with a control group

L Engler 1, HE Kuenzel 1, A Riester 1, A Dietz 1, A Yassouridis 2, M Reinke 1, A Steiger 2
  • 1Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität München, München, Germany
  • 2Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany

Background: The renin-angiotensin-aldosterone system (RAAS) raised attention in several studies due to its connection to sleep patterns. In primary aldosteronism (PA), aldosterone secretion is enhanced significantly. Our aim was to investigate sleep patterns between patients suffering from PA in comparison to healthy volunteers (HV).

Methods: We compared 18 patients with untreated PA (11 males, 7 females) with HVs (11 male and 7 female subjects) matched according to age. After confirming diagnosis of PA in our hospital, patients' polysomnografies were recorded during two consecutive nights. Polysomnographic parameters were scored in 30-s epochs.

Results: Multivariate analyses of variance showed significant group differences concerning the parameters latency of wake after sleep onset (LWSO), light sleep (LS) during the whole night and during the 2nd night half and sleep period time (SPT) during the 2nd night half. The duration (in epochs) of SPT in the 2nd night half (PA: 469.33 vs. HV: 495.72; p = 0.025) and LS in both whole night (PA: 520.11 vs. HV: 567.67; p = 0.043) and 2nd night half (PA: 261.83 vs. HV: 303.89; p = 0.026) were diminished significantly in patients with PA compared to HV. Moreover, LWSO was raised significantly in patients with PA (PA: 73.11 vs. HV: 31.61; p = 0.028).

Conclusions: Our data demonstrate that patients with PA suffer from disturbed sleep patterns. Whereas in healthy subjects, the aldosterone and cortisol peaks occur synchronously during the early morning, aldosterone peaks in PA are present during day-time. The diminished SPT in the PA group in the morning hours might be related to the dysregulated aldosterone secretion.

*These Authors contributed equally to the work