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Examination and management tactics of patients with adrenal incidentaloma
To determine biochemical and clinical criteria of hormonal activity and signs of malignancy of adrenal incidentalomas
To define sensitivity and specificity of the combination of standard methods to determine adrenal hormones with the study of steroid profiles by the methods of HPLC and GC-MS to reveal hormonal activity of adrenal formation
To refine the algorithm of clinical laboratory diagnostics and management of patients with adrenal incidentalomas.
Retro and prospective group research.
The research will be conducted on 150 male/female patients aged 18 or above with newly diagnosed adrenal incidentaloma formation, as well as patients annually examined on the adrenal incidentaloma formations.
Research Groups Formation:
Group: 30 patients with diagnosed incidentaloma, diagnosed 3 years ago
Group: 30 patients with hormonally inactive formations of adrenal incidentaloma diagnosed 2 years ago
Group: 30 patients with hormonally inactive formations of adrenal incidentaloma diagnosed a year ago
Group: 60 patients with newly diagnosed adrenal incidentalomas (30 patients with a size < 4 cm formations and 30 patients with a size > 4 cm formations).
Group: A control group comprised of 20 healthy males and females
CLIA – AKTH, FF in saliva, UFF, DEAS, Renin
ELISA -17-OHP, NMN, MN in blood and in urine
RIA- PAC, PRA
HPLC – level of F, E, B, 11-dehydrocoricosteron, 18-OHB, DOC and S in blood and FS, FB, 18-OHB, 6-β-OHF in urine
GC-MS – THF, allo-THF, THE, THB, THS, 17OHdA2, DHA, dA3, dP2, dP3, 16-OHdP2
Supresive test with 1, 2 mg of dexamethasone
Test with physiological (salt) solution
Visual diagnostic methods CT, MRI, Sonograph