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Laryngorhinootologie 2015; 94(06): 367-372
DOI: 10.1055/s-0035-1548921
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Zirkulierende Tumorzellen bei Kopf-Hals-Tumoren

Circulating Tumor Cells in Head and Neck Cancer
O. Guntinas-Lichius
1   Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Universitätsklinikum Jena
,
K. Pachmann
2   Transfusionsmedizinisches Zentrum Bayreuth, Bayreuth
› Author Affiliations
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Publication History

Publication Date:
03 June 2015 (online)

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Zusammenfassung

Tumorzellen, die im peripheren Blut von Tumorpatienten zirkulieren, bezeichnet man als zirkulierende Tumorzellen. Während bei einer Reihe von anderen soliden Tumoren die Bedeutung zirkulierender Tumorzellen schon weitreichend untersucht ist, ist deren Bedeutung bei Kopf-Hals-Karzinomen erst in den letzten Jahren in den wissenschaftlichen Fokus gerückt. Bei anderen soliden Tumoren hat der Nachweis von zirkulierenden Tumorzellen eine prognostische Relevanz und scheint auch ein Marker für Therapieansprechen zu sein. Dieser Artikel gibt eine Übersicht darüber, was wir bislang über die klinische Relevanz von zirkulierenden Tumorzellen bei Kopf-Hals-Tumoren wissen. Die Methoden zur Detektion werden kritisch beleuchtet und das zukünftige Potential des Nachweises dieser Tumorzellen wird diskutiert.

Abstract

Circulating tumor cells are defined as tumor cells which are circulating in the peripheral blood of the cancer patient. While several large studies have investigated the role of circulating tumor cells in other solid tumors, the importance of these tumor cells in patients with head and neck cancer was turned into the focus not until the recent years. In other solid tumor the presence of circulating tumor cells often seems to be a negative prognostic marker and seems to be a marker for therapy response. The present article wants to give an overview about the knowledge on circulating tumor cells and their clinical relevance in head and neck cancer. The methodology to detect circulating tumor cells will be critically reflected. The future potential of the detection of circulating tumor cells in head and neck cancer patients will be discussed.

Schlüsselwörter

Kopf-Hals-Tumoren - zirkulierende Tumorzellen - Metastasierung - Prognose - Überleben

Key words

head and neck cancer - circulating tumor cells - metastasis - prognosis - survival
 

  • Literatur

  • 1 Pantel K, Brakenhoff RH, Brandt B. Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nature Rev Cancer 2008; 8: 329-340
    CrossrefPubMedGoogle Scholar
  • 2 Husemann Y, Geigl JB, Schubert F et al. Systemic spread is an early step in breast cancer. Cancer Cell 2008; 13: 58-68
    CrossrefPubMedGoogle Scholar
  • 3 Meng S, Tripathy D, Frenkel EP et al. Circulating tumor cells in patients with breast cancer dormancy. Clin Cancer Res 2004; 10: 8152-8162
    CrossrefPubMedGoogle Scholar
  • 4 Spano D, Heck C, De Antonellis P et al. Molecular networks that regulate cancer metastasis. Semin Cancer Biol 2012; 22: 234-249
    CrossrefPubMedGoogle Scholar
  • 5 Chambers AF, Goss PE. Putative growth characteristics of micrometastatic breast cancer. Breast Cancer Res 2008; 10: 114
    CrossrefPubMedGoogle Scholar
  • 6 Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nature Rev Cancer 2002; 2: 563-572
    CrossrefPubMedGoogle Scholar
  • 7 Sosa MS, Bragado P, Aguirre-Ghiso JA. Mechanisms of disseminated cancer cell dormancy: an awakening field. Nature Rev Cancer 2014; 14: 611-622
    CrossrefPubMedGoogle Scholar
  • 8 Weller P, Nel I, Hassenkamp P et al. Detection of circulating tumor cell subpopulations in patients with head and neck squamous cell carcinoma (HNSCC). PloS one 2014; 9: e113706
    CrossrefPubMedGoogle Scholar
  • 9 Mockelmann N, Laban S, Pantel K et al. Circulating tumor cells in head and neck cancer: clinical impact in diagnosis and follow-up. Eur Arch Otorhinolaryngol 2014; 271: 15-21
    CrossrefPubMedGoogle Scholar
  • 10 Balasubramanian P, Lang JC, Jatana KR et al. Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck. PloS one 2012; 7: e42048
    CrossrefPubMedGoogle Scholar
  • 11 Pachmann K, Clement JH, Schneider CP et al. Standardized quantification of circulating peripheral tumor cells from lung and breast cancer. Clinical chemistry and laboratory medicine: CCLM/FESCC 2005; 43: 617-627
    PubMedGoogle Scholar
  • 12 Lowes LE, Allan AL. Recent advances in the molecular characterization of circulating tumor cells. Cancers 2014; 6: 595-624
    CrossrefPubMedGoogle Scholar
  • 13 Shao MM, Chan SK, Yu AM et al. Keratin expression in breast cancers. Virch Arch 2012; 461: 313-322
    CrossrefPubMedGoogle Scholar
  • 14 Munz M, Baeuerle PA, Gires O. The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res 2009; 69: 5627-5629
    CrossrefPubMedGoogle Scholar
  • 15 Wang X, Qian X, Beitler JJ et al. Detection of circulating tumor cells in human peripheral blood using surface-enhanced Raman scattering nanoparticles. Cancer Res 2011; 71: 1526-1532
    CrossrefPubMedGoogle Scholar
  • 16 Gorges TM, Tinhofer I, Drosch M et al. Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition. BMC Cancer 2012; 12: 178
    CrossrefPubMedGoogle Scholar
  • 17 Sieuwerts AM, Kraan J, Bolt J et al. Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells. J Natl Cancer Inst 2009; 101: 61-66
    CrossrefPubMedGoogle Scholar
  • 18 Mehes G, Witt A, Kubista E et al. Circulating breast cancer cells are frequently apoptotic. Am J Pathol 2001; 159: 17-20
    CrossrefPubMedGoogle Scholar
  • 19 Buglione M, Grisanti S, Almici C et al. Circulating tumour cells in locally advanced head and neck cancer: preliminary report about their possible role in predicting response to non-surgical treatment and survival. Eur J Cancer 2012; 48: 3019-3026
    CrossrefPubMedGoogle Scholar
  • 20 Hristozova T, Konschak R, Stromberger C et al. The presence of circulating tumor cells (CTCs) correlates with lymph node metastasis in nonresectable squamous cell carcinoma of the head and neck region (SCCHN). Ann Oncol 2011; 22: 1878-1885
    CrossrefPubMedGoogle Scholar
  • 21 Tinhofer I, Konschak R, Stromberger C et al. Detection of circulating tumor cells for prediction of recurrence after adjuvant chemoradiation in locally advanced squamous cell carcinoma of the head and neck. Ann Oncol 2014; 25: 2042-2047
    CrossrefPubMedGoogle Scholar
  • 22 Oertel K, Spiegel K, Schmalenberg H et al. Phase I trial of split-dose induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1). BMC Cancer 2012; 12: 483
    CrossrefPubMedGoogle Scholar
  • 23 Kusukawa J, Suefuji Y, Ryu F et al. Dissemination of cancer cells into circulation occurs by incisional biopsy of oral squamous cell carcinoma. J Oral Pathol Med 2000; 29: 303-307
    CrossrefPubMedGoogle Scholar
  • 24 Liu Z, Jiang M, Zhao J et al. Circulating tumor cells in perioperative esophageal cancer patients: quantitative assay system and potential clinical utility. Clin Cancer Res 2007; 13: 2992-2997
    CrossrefPubMedGoogle Scholar
  • 25 Hashimoto M, Tanaka F, Yoneda K et al. Significant increase in circulating tumour cells in pulmonary venous blood during surgical manipulation in patients with primary lung cancer. Interact Cardiovasc Thorac Surg 2014; 18: 775-783
    CrossrefPubMedGoogle Scholar
  • 26 Nesteruk D, Rutkowski A, Fabisiewicz S et al. Evaluation of prognostic significance of circulating tumor cells detection in rectal cancer patients treated with preoperative radiotherapy: prospectively collected material data. BioMed Res Int 2014; 2014: 712827
    PubMedGoogle Scholar
  • 27 Tinhofer I, Hristozova T, Stromberger C et al. Monitoring of circulating tumor cells and their expression of EGFR/phospho-EGFR during combined radiotherapy regimens in locally advanced squamous cell carcinoma of the head and neck. Int J Rad Oncol Biol Phys 2012; 83: e685-e690
    CrossrefPubMedGoogle Scholar
  • 28 Jatana KR, Balasubramanian P, Lang JC et al. Significance of circulating tumor cells in patients with squamous cell carcinoma of the head and neck: initial results. Arch Otolaryngol Head Neck Surg 2010; 136: 1274-1279
    CrossrefPubMedGoogle Scholar
  • 29 Nichols AC, Lowes LE, Szeto CC et al. Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system. Head Neck 2012; 34: 1440-1444
    CrossrefPubMedGoogle Scholar
  • 30 Grobe A, Blessmann M, Hanken H et al. Prognostic relevance of circulating tumor cells in blood and disseminated tumor cells in bone marrow of patients with squamous cell carcinoma of the oral cavity. Clin Cancer Res 2014; 20: 425-433
    CrossrefPubMedGoogle Scholar
  • 31 Grisanti S, Almici C, Consoli F et al. Circulating tumor cells in patients with recurrent or metastatic head and neck carcinoma: prognostic and predictive significance. PloS one 2014; 9: e103918
    CrossrefPubMedGoogle Scholar
  • 32 Hsieh JC, Lin HC, Huang CY et al. Prognostic value of circulating tumor cells with podoplanin expression in patients with locally advanced or metastatic head and neck squamous cell carcinoma Head Neck. 2014 DOI: DOI: 10.1002/hed.23779 epub ehead of print
    PubMedGoogle Scholar
  • 33 Paterlini-Brechot P.. About seed and soil. Cancer Microenviron 2014; 7: 91-93
    CrossrefPubMedGoogle Scholar
  • 34 Noman MZ, Messai Y, Muret J et al. Crosstalk between CTC, Immune System and Hypoxic Tumor Microenvironment. Cancer Microenviron 2014; 7: 153-160
    CrossrefPubMedGoogle Scholar
  • 35 Greene BT, Hughes AD, King MR. Circulating tumor cells: the substrate of personalized medicine?. Front Oncol 2012; 2: 69
    PubMedGoogle Scholar
  • 36 Paterlini-Brechot P. Circulating Tumor Cells: Who is the Killer?. Cancer Microenviron 2014; 7: 161-176
    CrossrefPubMedGoogle Scholar
  • 37 Wikner J, Grobe A, Pantel K et al. Squamous cell carcinoma of the oral cavity and circulating tumour cells. World J Clin Oncol 2014; 5: 114-124
    CrossrefPubMedGoogle Scholar
  • 38 Pajonk F, Schlessmann S, Guttenberger R et al. Epithelial cells in the peripheral blood of patients with cancer of the head and neck: incidence, detection and possible clinical significance. Radiother Oncol 2001; 59: 213-217
    CrossrefPubMedGoogle Scholar
  • 39 Partridge M, Brakenhoff R, Phillips E et al. Detection of rare disseminated tumor cells identifies head and neck cancer patients at risk of treatment failure. Clin Cancer Res 2003; 9: 5287-5294
    PubMedGoogle Scholar
  • 40 Guney K, Yoldas B, Ozbilim G et al. Detection of micrometastatic tumor cells in head and neck squamous cell carcinoma. A possible predictor of recurrences?. Saudi Med J 2007; 28: 216-220
    PubMedGoogle Scholar
  • 41 Dyavanagoudar S, Kale A, Bhat K et al. Reverse transcriptase polymerase chain reaction study to evaluate dissemination of cancer cells into circulation after incision biopsy in oral squamous cell carcinoma. Indian J Dent Res 2008; 19: 315-319
    CrossrefPubMedGoogle Scholar
  • 42 Hristozova T, Konschak R, Budach V et al. A simple multicolor flow cytometry protocol for detection and molecular characterization of circulating tumor cells in epithelial cancers. Cytometry 2012; 81: 489-495
    PubMedGoogle Scholar
  • 43 Bozec A, Ilie M, Dassonville O et al. Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol 2013; 270: 2745-2749
    CrossrefPubMedGoogle Scholar
  • 44 He S, Li P, He S et al. Detection of circulating tumour cells with the CellSearch system in patients with advanced-stage head and neck cancer: preliminary results. J Laryngol Otol 2013; 127: 788-793
    CrossrefPubMedGoogle Scholar