Am J Perinatol 2015; 32(11): 1031-1037
DOI: 10.1055/s-0035-1547324
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

CRIB Scores as a Tool for Assessing Risk for the Development of Pulmonary Hypertension in Extremely Preterm Infants with Bronchopulmonary Dysplasia

Christie J. Bruno
1   Division of Neonatology, Department of Pediatrics, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York
*   These authors have equal contributions.
,
Meera Meerkov
2   Department of Pediatrics, The Children's Hospital at Montefiore, Bronx, New York
,
Christine Capone
3   Division of Cardiology, Department of Pediatrics, The Children's Hospital at Montefiore, Bronx, New York
*   These authors have equal contributions.
,
Melissa Vega
1   Division of Neonatology, Department of Pediatrics, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York
,
Nicole Sutton
3   Division of Cardiology, Department of Pediatrics, The Children's Hospital at Montefiore, Bronx, New York
,
Mimi Kim
4   Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York
,
Dan Wang
4   Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York
,
Mamta Fuloria
1   Division of Neonatology, Department of Pediatrics, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York
› Author Affiliations
Further Information

Publication History

28 August 2014

14 January 2015

Publication Date:
08 May 2015 (online)

Abstract

Objective Bronchopulmonary dysplasia (BPD) increases the risk for developing pulmonary hypertension (PH). However, the risk factors associated with BPD-associated PH remain unclear. Our primary aim was to determine perinatal risk factors associated with the development of PH in infants with BPD.

Study Design We retrospectively reviewed medical records of 303 infants born at ≤ 28 weeks' gestation. Infants were categorized as having no, mild, moderate, or severe BPD. PH was diagnosed by echocardiogram. Data were analyzed using Fisher exact test, two-sample t-test, and multivariable logistic regression.

Results The incidence of PH in our cohort was 12%. Infants with PH had lower birth weights and gestational ages (p < 0.001). After controlling for confounding variables, severe BPD (p < 0.001), and higher Clinical Risk Index for Babies (CRIB) scores (p = 0.04) were associated with the development of PH.

Conclusion Severe BPD increases the risk for developing PH. Higher CRIB scores correlate with PH development in infants with BPD. We speculate that CRIB scores may allow for early categorization of preterm infants with a higher likelihood of developing PH.

 
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