Klin Padiatr 2015; 227(03): 173-175
DOI: 10.1055/s-0035-1547307
Case Report
© Georg Thieme Verlag KG Stuttgart · New York

Eosinophilic Esophagitis as Paraneoplastic Syndrome in a Patient with Ganglioneuroblastoma

Eosinophile Ösophagitis als paraneoplastisches Syndrom bei Ganglioneuroblastom
S. Prader
1   Immunology, University Children’s Hospital Zurich, Zurich, Switzerland
J. Spalinger
3   Gastroenterology, Children’s Hospital Lucerne, Lucerne, Switzerland
J. Caduff
4   Radiology, Hospital Lucerne, Lucerne, Switzerland
S. Hürlimann
5   Pathology, Hospital Lucerne, Lucerne, Switzerland
J. Rischewski
2   Pediatric Haematology and Oncology, Cantonal Hospital Lucerne, Lucerne, Switzerland
› Author Affiliations
Further Information

Publication History

Publication Date:
18 May 2015 (online)


A 16-month-old boy presented with failure to thrive despite sufficient caloric intake, hypersalivation, abdominal pain, chronic diarrhea and blepharitis. An eosinophilic esophagitis (EoE) was diagnosed by esophageal biopsy. Dietary restrictions and topical steroid treatment lead to no improvement. Further diagnostic work-up revealed an intrathoracal, paraspinal ganglioneuroblastoma. After operative extirpation of the tumour, all initial symptoms resolved. An esophageal control biopsy 4 weeks after tumour resection was normal. This is the first report of eosinophilic esophagitis as part of a paraneoplastic syndrome in a patient with a malignant disease other than a carcinoma.