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Int Arch Otorhinolaryngol 2015; 19(02): 130-134
DOI: 10.1055/s-0035-1546432
Original Research
Thieme Publicações Ltda Rio de Janeiro, Brazil

Surfactant Protein A Expression in Chronic Rhinosinusitis and Atrophic Rhinitis

Mohammad Waheed El-Anwar
1   Department of Otorhinolaryngology, Head and Neck Surgery, Zagazig University, Zagazig, Egypt
,
Atef A. Hamed
1   Department of Otorhinolaryngology, Head and Neck Surgery, Zagazig University, Zagazig, Egypt
,
Abd ElRaof Said Mohamed
1   Department of Otorhinolaryngology, Head and Neck Surgery, Zagazig University, Zagazig, Egypt
,
Ahmad Abdel-Fattah Nofal
1   Department of Otorhinolaryngology, Head and Neck Surgery, Zagazig University, Zagazig, Egypt
,
Maha A. Mohamed
2   Department of Clinical Pathology, Zagazig University, Zagazig, Egypt
,
Hesham R. Abdel-Aziz
3   Department of Pathology, Zagazig University, Zagazig, Egypt
› Author Affiliations
Further Information

Publication History

23 November 2014

10 January 2015

Publication Date:
20 February 2015 (online)

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Abstract

Introduction Surfactant protein A (SP-A) exhibits antimicrobial properties and interacts with a variety of respiratory tract pathogens.

Objective The objective of this study was to detect the presence of SP-A and measure its alterations in chronic rhinosinusitis (CRS) and primary atrophic rhinitis (PAR) versus healthy controls.

Methods Inferior turbinate and sinus mucosal biopsies were taken from 30 patients with CRS, 30 patients with PAR, and 20 healthy controls. Immunohistochemical staining for SP-A and polymerase chain reaction (PCR) amplification of SP-A messenger RNA were performed on nasal tissue samples.

Results Immunostaining localized SP-A to the mucosa and submucosal glands in CRS specimens but failed to localize it in PAR specimens. Quantitative PCR showed a high, statistically significant increase in the SP-A levels of patients with CRS when compared with controls (p < 0.0001) and also demonstrated a significant reduction of SP-A in patients with PAR compared with controls (p < 0.005).

Conclusion SP-A is significantly increased in CRS and decreased significantly in PAR and appears to be expressed by respiratory epithelial cells and submucosal glandular elements of the sinonasal mucosa. The potential therapeutic applications of surfactant in the enhancement of mucociliary clearance need to be studied.

Keywords

sinusitis - rhinitis - nose
 

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