pferde spiegel 2015; 18(1): 22-31
DOI: 10.1055/s-0035-1545701
ps.cve
Enke Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG Stuttgart · New York

Magengeschwüre beim Pferd – Ein Update

Charlotte Hopster-Iversen
Further Information

Publication History

Publication Date:
13 March 2015 (online)

Magengeschwüre (EGUS = Equine Gastric Ulcer Syndrome) stellen die häufigste Erkrankung des Magens beim Pferd dar und haben je nach untersuchter Pferdepopulation und Nutzungsart der Tiere eine hohe bis sehr hohe Prävalenz [13] . Im Rahmen dieses Artikels sollen relevante Ergebnisse verschiedener Studien der letzten Jahre zusammengefasst und diskutiert werden.

 
  • Literatur

  • 1 Andrews FM, Nadeau JA. Clinical syndromes of gastric ulceration in foals and mature horses. Equine Vet J 1999; 31 (S29) 30-33
  • 2 Andrews FM, Camacho P, Gaymon G et al. Effects of SmartGut® Ultra on non-glandular gastric ulcer score and gastric juice pH. Abstract 11th International Equine Colic Research Symposium, 2014: Dublin 7th–10th July.
  • 3 Andrews FM, Camacho P, Loftin P et al. Evaluation of a replacement of supplemental inorganic minerals and performance minerals on equine gastric ulcers. Abstract 11th International Equine Colic Research Symposium, 2014: Dublin 7th–10th July.
  • 4 Bell RJW, Mogg TD, Kingston JK. Equine gastric ulcer syndrome in adult horses: a review. N Z Vet J 2007; 55 (1) 1-12
  • 5 Birkmann K, Junge HK, Maischberger E et al. Efficacy of Omeprazole Powder Paste or Enteric-Coated Formulation in Healing of Gastric Ulcers in Horses. J Vet Intern Med 2014; 28 (3) 925-933
  • 6 Bullimore SR, Corfield AP, Hicks SJ et al. Surface mucus in the non-glandular region of the equine stomach. Res Vet Sci 2001; 70 (2) 149-155
  • 7 Chameroy KA, Nadeau JA, Bushmich SL et al. Prevalence of non-glandular gastric ulcers in horses involved in a university riding program. J Equine Vet Sci 2006; 26 (5) 207-211
  • 8 Dahlkamp M, Feige K, Venner M. Vorkommen von Magengeschwüren beim Absetzfohlen und deren Beeinflussung durch die Gabe von Omeprazol. Pferdeheilkunde 2012; 28 (5) 561-569
  • 9 Daurio CP, Holste JE, Andrews FM et al. Effect of omeprazole paste on gastric acid secretion in horses. Equine Vet J 1999; 31 (S29) 59-62
  • 10 Dionne RM, Vrins A, Doucet MY, Pare J. Gastric ulcers in Standardbred racehorses: prevalence, lesion description, and risk factors. J Vet Intern Med 2003; 17 (2) 218-222
  • 11 Doucet MY, Vrins AA, Dionne R et al. Efficacy of a paste formulation of omeprazole for the treatment of naturally occurring gastric ulcers in training standardbred racehorses in Canada. Can Vet J 2003; 44 (7) 581-585
  • 12 Duran SH. Famotidine. Compend Contin Educ Vet 1999; 21: 424-425
  • 13 Equine Gastric Ulcer Council. Recommendations for the diagnosis and treatment of equine gastric ulcer syndrome (EGUS). Equine Vet Educ 1999; 11 (5) 262-272
  • 14 Ethell MT, Hodgson DR, Hills BA. Evidence for surfactant contributing to the gastric mucosal barrier of the horse. Equine Vet J 2000; 32 (6) 470-474
  • 15 Frey HH, Löscher W. Lehrbuch der Pharmakologie und Toxikologie für die Veterinärmedizin. 3. Aufl.. Stuttgart: Enke; 2010: 275
  • 16 Gehlen H, Schmitz R, Kläring A. Auswirkungen von Kolik auf die Entstehung von Magenulzera (EGUS) beim Pferd. Pferdeheilkunde 2014; 4: 368-380
  • 17 Gillen D, Wirz AA, Ardill JE, McColl KE. Rebound hypersecretion after omeprazole and its relation to on-treatment acid suppression and Helicobacter pylori status. Gastroenterology 1999; 116: 239-247
  • 18 Habershon-Butcher JL, Hallowell GD, Bowen IM, Sykes B. Prevalence and risk factors for ulceration of the gastric glandular mucosa in thoroughbred racehorses in training in the UK and Australia. In: ACVIM Research Forum Abstracts 2012. J Vet Intern Med 2012; 26 (4) 690-822
  • 19 Hepburn R. Endoscopic examination of the squamous and glandular gastric mucosa in sport and leisure horses: 684 horses (2005 – 2011). Abstract 11th International Equine Colic Research Symposium, 2014: Dublin 7th–10th July.
  • 20 Hepburn R. Treatment of Ulceration of the Gastric Glandular Mucosa: Retrospective evaluation of omeprazole and sucralfate combination therapy in 204 sport and leisure horses. Abstract 11th International Equine Colic Research Symposium, 2014: Dublin 7th–10th July.
  • 21 Hewetson M, Cohen ND, Love S et al. Sucrose concentration in blood: A new method for assessment of gastric permeability in horses with gastric ulceration. J Vet Intern Med 2006; 20 (2) 388-94
  • 22 Hewetson M, Aaltonen K, Tulamo RM, Sankari S. Development and validation of a gas chromatography–flame ionization detection method for quantifying sucrose in equine serum. J Vet Diagn Invest 2014; 26 (2) 232-239
  • 23 Kitamura N, Yamada J, Calingasan NY, Yamashita T. Immunocytochemical distribution of endocrine cells in the gastrointestinal tract of the horse. Equine Vet J 1984; 16 (2) 103-7
  • 24 Le Jeune SS, Nieto JE, Dechant JE, Snyder JR. Prevalence of gastric ulcers in Thoroughbred broodmares in pasture: A preliminary report. Vet J 2009; 181 (3) 251-255
  • 25 Lorenzo-Figueras M, Merritt AM. Effects of exercise on gastric volume and pH in the proximal portion of the stomach of horses. Am J Vet Res 2002; 63 (11) 1481-1487
  • 26 Luthersson N, Nielsen KH, Harris P, Parkin TDH. The prevalence and anatomical distribution of equine gastric ulceration syndrome (EGUS) in 201 horses in Denmark. Equine Vet J 2009; 41 (7) 619-624
  • 27 Luthersson N, Nielsen KH, Harris P, Parkin TDH. Risk factors associated with equine gastric ulceration syndrome (EGUS) in 201 horses in Denmark. Equine Vet J 2009; 41 (7) 625-630
  • 28 MacAllister CG. A review of medical treatment for peptic ulcer disease. Equine Vet J 1999; 31 (S29) 45-49
  • 29 McClure SR, Glickman LT, Glickman NW. Prevalence of gastric ulcers in show horses. J Am Vet Med Assoc 1999; 215 (8) 1130-1133
  • 30 McClure SR, Carithers DS, Gross SJ, Murray MJ. Gastric ulcer development in horses in a simulated show or training environment. J Am Vet Med Assoc 2005; 227 (5) 775-777
  • 31 Merritt AM. Normal equine gastroduodenal secretion and motility. Equine Vet J 1999; 31 (S29) 7-13
  • 32 Merritt AM. Appeal for proper usage of the term ‘EGUS’: Equine gastric ulcer syndrome. Equine Vet J 2009; 41 (7) 616
  • 33 Miller TA. Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol 1983; 245: G601-G623
  • 34 Murray MJ, Grodinsky C, Anderson CW et al. Gastric ulcers in horses: a comparison of endoscopic findings in horses with and with- out clinical signs. Equine Vet J 1989; 21 (S7) 68-72
  • 35 Murray MJ, Murray CM, Sweeney HJ et al. Prevalence of gastric lesions in foals without signs of gastric disease: An endoscopic survey. Equine Vet J 1990; 22 (1) 6-8
  • 36 Murray MJ, Mahaffey EA. Age-related characteristics of gastric squamous epithelial mucosa in foals. Equine Vet J 1993; 25 (6) 514-517
  • 37 Murray MJ, Schusser GF. Measurement of 24-h gastric pH using an indwelling pH electrode in horses unfed, fed and treated with ranitidine. Equine Vet J 1993; 25 (5) 417-421
  • 38 Murray MJ, Eichorn ES. Effects of intermittent feed deprivation, intermittent feed deprivation with ranitidine administration, and stall confinement with ad libitum access to hay on gastric ulceration in horses. Am J Vet Res 1996; 57 (11) 1599-1603
  • 39 Murray MJ. Gastroduodenal ulcerations in foals. Equine Vet Educ 1999; 11 (4) 199-207
  • 40 Murray MJ. Pathophysiology of peptic disorders in foals and horses: a review. Equine Vet J 1999; 31 (S29) 14-18
  • 41 Murray MJ, Nout YS, Ward DL. Endoscopic findings of the gastric antrum and pylorus in horses: 162 cases (1996–2000). J Vet Intern Med 2001; 15 (4) 401-406
  • 42 Murray MJ. Drugs acting on the gastrointestinal system. In: Bertone J, Horspool L, eds. Equine Clinical Pharmacology. London, UK: WB Saunders; 2004: 85-120
  • 43 Nicol CJ, Davidson HPD, Harris PA et al. Study of crib-biting and gastric inflammation and ulceration in young horses. Vet Rec 2002; 151 (22) 658-662
  • 44 Nickel R, Schummer A, Seiferle E. Lehrbuch der Anatomie der Haussäugetiere, Band 2: Eingeweide. 9. Aufl.. Stuttgart: Enke; 2004
  • 45 Nieto JE, Spier S, Pipers FS et al. Comparison of paste and suspension formulations of omeprazole in the healing of gastric ulcers in racehorses in active training. J Am Vet Med Assoc 2002; 221 (8) 1139-1143
  • 46 OʼConnor MS, Steiner JM, Roussel AJ et al. Evaluation of urine sucrose concentration for detection of gastric ulcers in horses. Am J Vet Res 2004; 65 (1) 31-39
  • 47 Orsini JA, Haddock M, Stine L et al. Odds of moderate or severe gastric ulceration in racehorses receiving antiulcer medication. J Am Vet Med Assoc 2003; 223 (3) 336-339
  • 48 Rabon EC, Reuben MA. The mechanism and structure of the gastric H, K-ATPase. Ann Rev Physiol 1990; 52 (1) 321-344
  • 49 Rabuffo TS, Hackett ES, Grenager N et al. Prevalence of gastric ulcerations in horses with colic. J Equine Vet Sci 2009; 29 (6) 540-546
  • 50 Sandin A, Skidell J, Haggstrom J, Nilsson G. Postmortem findings of gastric ulcers in Swedish horses older than age one year: A retrospective study of 3715 horses (1924–1996). Equine Vet J 2000; 32 (1) 36-42
  • 51 Schusser GF, May M, Rechnagel ST. Endoscopic and histologic observations in gastritis of horses. Abstract 11th International Equine Colic Research Symposium, 2014: Dublin, 7th–10th July.
  • 52 Sykes BW, Sykes KM, Hallowell GD. Efficacy of a Combination of a Unique Pectin-Lecithin Complex (Apolectol®), Live Yeast and Magnesium Hydroxide in the Prevention of EGUS and Faecal Acidosis in Thoroughbred Racehorses: A Randomised, Blinded, Placebo Controlled Clinical Trial. Abstract of the BEVA Congress 2013. Equine Vet J 2013; 45 (S44) 13
  • 53 Sykes BW, Sykes KM, Hallowell GD. A comparison of two doses of omeprazole in the treatment of equine gastric ulcer syndrome: A blinded, randomised, clinical trial. Equine Vet J 2014; 46 (4) 416-421
  • 54 Sykes BW, Sykes KM, Hallowell GD. A comparison of three doses of omeprazole in the treatment of equine gastric ulcer syndrome: A blinded, randomised, dose–response clinical trial. Equine Vet J 2014; DOI: 10.1111/evj.12287.
  • 55 Sykes B et al. Equine Gastric Ulceration Syndrome Consensus. 7th ECEIM Congress 2014: Prague, 6. – 8. November.
  • 56 Taharaguchi S, Nagano S, Okai A et al. Detection of an isoform of α1-antitrypsin in serum samples from foals with gastric ulcers. Vet Rec 2007; 161 (10) 338-341
  • 57 Tamzali Y, Marguet C, Priymenko N, Lyazrry F. Prevalence of gastric ulcer syndrome in high-level endurance horses. Equine Vet J 2011; 43 (2) 141-144
  • 58 Toewe BH. Ursachen und Funktionen von Koppen bei Pferden und Möglichkeiten und Grenzen der Prävention und Therapie [Dissertation]. Gießen: Justus-Liebig-Universität Gießen; 2013
  • 59 Vatistas NJ, Snyder JR, Carlson G et al. Cross-sectional study of gastric ulcers of the squamous mucosa in Thoroughbred racehorses. Equine Vet J 1999; 31 (S29) 34-39
  • 60 White G, McClure SR, Sifferman R et al. Effects of short-term light to heavy exercise on gastric ulcer development in horses and efficacy of omeprazole paste in preventing gastric ulceration. J Am Vet Med Assoc 2007; 230 (11) 1680-1682