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Planta Med 2015; 81 - PC13
DOI: 10.1055/s-0035-1545200
DOI: 10.1055/s-0035-1545200
Anticancer metabolites from Achillea fragrantissima
Some Egyptian plants were screened for their anticancer activity using Sulpho-Rhodamine-B assay. The extracts of Achillea fragrantissima were shown to possess anticancer activity. Bioactivity-guided fractionation of A. fragrantissima methanolic extract led to the isolation of four flavonoids (1 – 4). The structure elucidation of the isolated flavonoids were achieved using spectroscopic techniques, including 1D and 2D NMR and HRMS. Their chemical structures were identified as, cirsiliol (1), chrysosplenol D (2), eupatilin-7-methylether (3), and cirsimaritin (4). The isolated compounds were tested against MCF-7, A549, HELA, PC3, and HEPG2 cancer cell lines with IC50 values ranging from
3.23 to 28.30 µg/mL.