Planta Med 2015; 81 - PC13
DOI: 10.1055/s-0035-1545200

Anticancer metabolites from Achillea fragrantissima

B Awad 1, AK Ibrahim 2, E Sand 2, AS Wanas 3, 4, MM Radwan 3, 5, M Elsohaly 3, 6, SA Ahmed 2
  • 1Department of Pharmacognosy, Faculty of Pharmacy, Sinai University, 55441 North Sinai, Egypt
  • 2Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, 41522 Ismailia, Egypt
  • 3National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA
  • 4Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt
  • 5Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
  • 6Department of Pharmaceutics, School of Pharmacy, University of Mississippi, MS 38677, USA

Some Egyptian plants were screened for their anticancer activity using Sulpho-Rhodamine-B assay. The extracts of Achillea fragrantissima were shown to possess anticancer activity. Bioactivity-guided fractionation of A. fragrantissima methanolic extract led to the isolation of four flavonoids (1 – 4). The structure elucidation of the isolated flavonoids were achieved using spectroscopic techniques, including 1D and 2D NMR and HRMS. Their chemical structures were identified as, cirsiliol (1), chrysosplenol D (2), eupatilin-7-methylether (3), and cirsimaritin (4). The isolated compounds were tested against MCF-7, A549, HELA, PC3, and HEPG2 cancer cell lines with IC50 values ranging from

3.23 to 28.30 µg/mL.

Fig. 1