Semin Plast Surg 2015; 29(01): 040-047
DOI: 10.1055/s-0035-1544169
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Principles of Nerve Repair in Complex Wounds of the Upper Extremity

Amy M. Moore
1   Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri
,
I. Janelle Wagner
1   Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri
,
Ida K. Fox
1   Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri
› Author Affiliations
Further Information

Publication History

Publication Date:
04 February 2015 (online)

Abstract

Peripheral nerve injuries are common in the setting of complex upper extremity trauma. Early identification of nerve injuries and intervention is critical for maximizing return of function. In this review, the principles of nerve injury, patient evaluation, and surgical management are discussed. An evidence-based approach to nerve reconstruction is reviewed, including the benefits and limitations of direct repair and nerve gap reconstruction with the use of autografts, processed nerve allografts, and conduits. Further, the principles and indications of commonly used nerve transfers in proximal nerve injuries are also addressed.

 
  • References

  • 1 Fox IK, Mackinnon SE. Adult peripheral nerve disorders: nerve entrapment, repair, transfer, and brachial plexus disorders. Plast Reconstr Surg 2011; 127 (5) 105e-118e
  • 2 Moore AM, Novak CB. Advances in nerve transfer surgery. J Hand Ther 2014; 27 (2) 96-104 , quiz 105
  • 3 Mackinnon SE. New directions in peripheral nerve surgery. Ann Plast Surg 1989; 22 (3) 257-273
  • 4 Secer HI, Daneyemez M, Tehli O, Gonul E, Izci Y. The clinical, electrophysiologic, and surgical characteristics of peripheral nerve injuries caused by gunshot wounds in adults: a 40-year experience. Surg Neurol 2008; 69 (2) 143-152 , discussion 152
  • 5 Bercik MJ, Kingsbery J, Ilyas AM. Peripheral nerve injuries following gunshot fracture of the humerus. Orthopedics 2012; 35 (3) e349-e352
  • 6 Seddon HJ, Medawar PB, Smith H. Rate of regeneration of peripheral nerves in man. J Physiol 1943; 102 (2) 191-215
  • 7 Kobayashi J, Mackinnon SE, Watanabe O , et al. The effect of duration of muscle denervation on functional recovery in the rat model. Muscle Nerve 1997; 20 (7) 858-866
  • 8 Fu SY, Gordon T. Contributing factors to poor functional recovery after delayed nerve repair: prolonged denervation. J Neurosci 1995; 15 (5 Pt 2) 3886-3895
  • 9 Bailey R, Kaskutas V, Fox I, Baum CM, Mackinnon SE. Effect of upper extremity nerve damage on activity participation, pain, depression, and quality of life. J Hand Surg Am 2009; 34 (9) 1682-1688
  • 10 Campbell WW. Evaluation and management of peripheral nerve injury. Clin Neurophysiol 2008; 119 (9) 1951-1965
  • 11 Willmott AD, White C, Dukelow SP. Fibrillation potential onset in peripheral nerve injury. Muscle Nerve 2012; 46 (3) 332-340
  • 12 Millesi H. Bridging defects: autologous nerve grafts. Acta Neurochir Suppl (Wien) 2007; 100: 37-38
  • 13 Brenner MJ, Hess JR, Myckatyn TM, Hayashi A, Hunter DA, Mackinnon SE. Repair of motor nerve gaps with sensory nerve inhibits regeneration in rats. Laryngoscope 2006; 116 (9) 1685-1692
  • 14 Nichols CM, Brenner MJ, Fox IK , et al. Effects of motor versus sensory nerve grafts on peripheral nerve regeneration. Exp Neurol 2004; 190 (2) 347-355
  • 15 Ray WZ, Mackinnon SE. Management of nerve gaps: autografts, allografts, nerve transfers, and end-to-side neurorrhaphy. Exp Neurol 2010; 223 (1) 77-85
  • 16 Kehoe S, Zhang XF, Boyd D. FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy. Injury 2012; 43 (5) 553-572
  • 17 Taras JS, Nanavati V, Steelman P. Nerve conduits. J Hand Ther 2005; 18 (2) 191-197
  • 18 Moore AM, MacEwan M, Santosa KB , et al. Acellular nerve allografts in peripheral nerve regeneration: a comparative study. Muscle Nerve 2011; 44 (2) 221-234
  • 19 Moore AM, Kasukurthi R, Magill CK, Farhadi HF, Borschel GH, Mackinnon SE. Limitations of conduits in peripheral nerve repairs. Hand (NY) 2009; 4 (2) 180-186
  • 20 Hudson TW, Zawko S, Deister C , et al. Optimized acellular nerve graft is immunologically tolerated and supports regeneration. Tissue Eng 2004; 10 (11-12) 1641-1651
  • 21 Krekoski CA, Neubauer D, Zuo J, Muir D. Axonal regeneration into acellular nerve grafts is enhanced by degradation of chondroitin sulfate proteoglycan. J Neurosci 2001; 21 (16) 6206-6213
  • 22 Neubauer D, Graham JB, Muir D. Chondroitinase treatment increases the effective length of acellular nerve grafts. Exp Neurol 2007; 207 (1) 163-170
  • 23 Whitlock EL, Tuffaha SH, Luciano JP , et al. Processed allografts and type I collagen conduits for repair of peripheral nerve gaps. Muscle Nerve 2009; 39 (6) 787-799
  • 24 Karabekmez FE, Duymaz A, Moran SL. Early clinical outcomes with the use of decellularized nerve allograft for repair of sensory defects within the hand. Hand (NY) 2009; 4 (3) 245-249
  • 25 Cho MS, Rinker BD, Weber RV , et al. Functional outcome following nerve repair in the upper extremity using processed nerve allograft. J Hand Surg Am 2012; 37 (11) 2340-2349
  • 26 Brooks DN, Weber RV, Chao JD , et al. Processed nerve allografts for peripheral nerve reconstruction: a multicenter study of utilization and outcomes in sensory, mixed, and motor nerve reconstructions. Microsurgery 2012; 32 (1) 1-14
  • 27 Kim DH, Kam AC, Chandika P, Tiel RL, Kline DG. Surgical management and outcome in patients with radial nerve lesions. J Neurosurg 2001; 95 (4) 573-583
  • 28 Ray WZ, Mackinnon SE. Clinical outcomes following median to radial nerve transfers. J Hand Surg Am 2011; 36 (2) 201-208
  • 29 Brown JM, Tung TH, Mackinnon SE. Median to radial nerve transfer to restore wrist and finger extension: technical nuances. Neurosurgery 2010; 66 (3, Suppl Operative): 75-83 , discussion 83
  • 30 Lowe III JB, Sen SK, Mackinnon SE. Current approach to radial nerve paralysis. Plast Reconstr Surg 2002; 110 (4) 1099-1113
  • 31 Brown JM, Mackinnon SE. Nerve transfers in the forearm and hand. Hand Clin 2008; 24 (4) 319-340 , v
  • 32 Boyd KU, Nimigan AS, Mackinnon SE. Nerve reconstruction in the hand and upper extremity. Clin Plast Surg 2011; 38 (4) 643-660
  • 33 Boutros S, Nath RK, Yüksel E, Weinfeld AB, Mackinnon SE. Transfer of flexor carpi ulnaris branch of the ulnar nerve to the pronator teres nerve: histomorphometric analysis. J Reconstr Microsurg 1999; 15 (2) 119-122
  • 34 Hsiao EC, Fox IK, Tung TH, Mackinnon SE. Motor nerve transfers to restore extrinsic median nerve function: case report. Hand (NY) 2009; 4 (1) 92-97
  • 35 Kapandji A. Biomechanics of pronation and supination of the forearm. Hand Clin 2001; 17 (1) 111-122 , vii
  • 36 Zheng XY, Hou CL, Gu YD, Shi QL, Guan SB. Repair of brachial plexus lower trunk injury by transferring brachialis muscle branch of musculocutaneous nerve: anatomic feasibility and clinical trials. Chin Med J (Engl) 2008; 121 (2) 99-104
  • 37 Ray WZ, Yarbrough CK, Yee A, Mackinnon SE. Clinical outcomes following brachialis to anterior interosseous nerve transfers. J Neurosurg 2012; 117 (3) 604-609
  • 38 García-López A, Sebastian P, Martinez F, Perea D. Transfer of the nerve to the brachioradialis muscle to the anterior interosseous nerve for treatment for lower brachial plexus lesions: case report. J Hand Surg Am 2011; 36 (3) 394-397
  • 39 Wang Y, Zhu S. Transfer of a branch of the anterior interosseus nerve to the motor branch of the median nerve and ulnar nerve. Chin Med J (Engl) 1997; 110 (3) 216-219
  • 40 Vernadakis AJ, Humphreys DB, Mackinnon SE. Distal anterior interosseous nerve in the recurrent motor branch graft for reconstruction of a median nerve neuroma-in-continuity. J Reconstr Microsurg 2004; 20 (1) 7-11
  • 41 Mackinnon SE, Colbert SH. Nerve transfers in the hand and upper extremity surgery. Tech Hand Up Extrem Surg 2008; 12 (1) 20-33
  • 42 Mannerfelt L. Studies on the hand in ulnar nerve paralysis. A clinical-experimental investigation in normal and anomalous innervation. Acta Orthop Scand 1966; (Suppl. 87) 87 , 1
  • 43 Gaul Jr JS. Intrinsic motor recovery—a long-term study of ulnar nerve repair. J Hand Surg Am 1982; 7 (5) 502-508
  • 44 Haase SC, Chung KC. Anterior interosseous nerve transfer to the motor branch of the ulnar nerve for high ulnar nerve injuries. Ann Plast Surg 2002; 49 (3) 285-290
  • 45 Novak CB, Mackinnon SE. Distal anterior interosseous nerve transfer to the deep motor branch of the ulnar nerve for reconstruction of high ulnar nerve injuries. J Reconstr Microsurg 2002; 18 (6) 459-464
  • 46 Battiston B, Lanzetta M. Reconstruction of high ulnar nerve lesions by distal double median to ulnar nerve transfer. J Hand Surg Am 1999; 24 (6) 1185-1191
  • 47 Farber SJ, Glaus SW, Moore AM, Hunter DA, Mackinnon SE, Johnson PJ. Supercharge nerve transfer to enhance motor recovery: a laboratory study. J Hand Surg Am 2013; 38 (3) 466-477
  • 48 Kale SS, Glaus SW, Yee A , et al. Reverse end-to-side nerve transfer: from animal model to clinical use. J Hand Surg Am 2011; 36 (10) 1631-1639.e2
  • 49 Barbour J, Yee A, Kahn LC, Mackinnon SE. Supercharged end-to-side anterior interosseous to ulnar motor nerve transfer for intrinsic musculature reinnervation. J Hand Surg Am 2012; 37 (10) 2150-2159
  • 50 Tung TH, Barbour JR, Gontre G, Daliwal G, Mackinnon SE. Transfer of the extensor digiti minimi and extensor carpi ulnaris branches of the posterior interosseous nerve to restore intrinsic hand function: case report and anatomic study. J Hand Surg Am 2013; 38 (1) 98-103
  • 51 Phillips BZ, Franco MJ, Yee A, Tung TH, Mackinnon SE, Fox IK. Direct radial to ulnar nerve transfer to restore intrinsic muscle function in combined proximal median and ulnar nerve injury: case report and surgical technique. J Hand Surg Am 2014; 39 (7) 1358-1362