Abstract
Objectives To identify factors associated with disease-specific survival (DSS) in intestinal
and nonintestinal sinonasal adenocarcinoma.
Design Retrospective review.
Setting Surveillance Epidemiology and End Results database.
Participants Adult patients with sinonasal adenocarcinoma.
Main Outcome Measures DSS.
Results We identified 325 patients; of these, 300 had the nonintestinal type and 25 had intestinal
type histologies. The 5-year DSS rates for patients who had no treatment, radiation
(RT), surgery, and surgery and postoperative RT were 42.5, 46.1, 85.6, and 72.6%,
respectively (log-rank test; p < 0.001). Black race, age ≥ 75 years, paranasal sinus involvement, and high grade
were independently associated with decreased DSS. Compared with RT, surgery (hazard
ratio [HR]: 0.34; 95% confidence interval [CI]: 0.15–0.77), and adjuvant RT (HR: 0.47;
95% CI, 0.26–0.86) were associated with improved DSS.
Conclusions There is no difference in prognosis between intestinal and nonintestinal subtypes
of sinonasal adenocarcinoma. Treatment with surgery alone or adjuvant RT is associated
with a more favorable prognosis.
Keywords
sinonasal - adenocarcinoma - intestinal type - nonintestinal type - survival
