Erkrankungen des rheumatischen Formenkreis mit Manifestation im Larynx

Zusammenfassung

Systemische Erkrankungen aus dem rheumatischen Formenkreis, wie eine rheumatoide Arthritis, eine Sarkoidose, ein Systemischer Lupus Erythematodes, eine Wegener Granulomatose und eine Relapsing Polychondritis können sich auch lokal im Larynx manifestieren. Da das klinische Erscheinungsbild häufig unspezifisch ist, wird die Diagnose oft erschwert bzw. deutlich verzögert gestellt. Differenzialdiagnostisch muss vor allem an Malignome gedacht werden, weshalb zur Diagnosesicherung häufig eine Probeexzision durchgeführt werden muss. Die Therapie solcher Erkrankungen erfolgt üblicherweise in enger Zusammenarbeit mit den Internisten bzw. den Rheumatologen.

Abstract

Rheumatic disorders (rheumatoid arthrits, sarcoidosis, systemic lupus erythematosus, Wegeners’s granulomatosis, relapsing polychondritis) may affect the larynx. The clinical symptoms are often unspecific, leading to delayed diagnosis. Malignant tumours should be considered in differential diagnosis with necessitating biopsy. Treatment may require interdisciplinary approach together with a specialist in internal medicine and rheumatology.

Schlüsselwörter

Larynx - Stimme - rheumatoide Arthritis - Sarkoidose - Systemischer Lupus Erythematodes

Key words

larynx - voice - rheumatoid arthritis - sarcoidosis - systemic lupus erythematosus

• Literatur

• 1 Smith E, Reiter R, Lindemann J, Brosch S. Dysphonie as a symptom of sarcoidosis. Laryngorhinootologie 2013; 92: 541-542
• 2 Reiter R, Stier KH, Brosch S. Hoarseness in patient with systemic lupus erythematosus. Laryngorhinootologie 2011; 90: 226-227
• 3 Murano E, Hosako-Naito Y, Tayama N, Oka T, Miyaji M, Kumada M, Niimi S. Bamboo node: primary vocal fold lesion as evidence of autoimmune disease. J Voice 2001; 15: 441-450
• 4 Hughes M, Hill J. Left vocal cord paralysis in systemic lupus erythematosus. Mod Rheumatol 2009; 19: 441-442
• 5 Peters JE, Salama AD, Ind PW. Wegener’s granulomatosis presenting as acute systemic vasculitis following 20 years of limited tracheobronchial disease. J Laryngol Otol 2009; 23: 1375-1377
• 6 Mrówka-Kata K, Kata D, Lange D, Namysłowski G, Czecior E, Banert K. Sarcoidosis and its otolaryngological implications. Eur Arch Otorhinolaryngol 2010; 267: 1507-1514
• 7 Loehrl TA, Smith TL. Inflammatory and granulomatous lesions of the larynx and pharynx. Am J Med 2001; 3; 111 (Suppl 8A) 113S-117S
• 8 Herold G. Innere Medizin. Köln: 2011: S1-S576
• 9 Ramos HV, Pillon J, Kosugi EM, Fujita R, Pontes P. Laryngeal assessment in rheumatic disease patients. Braz J Otorhinolaryngol 2005; 71: 499-503 25
• 10 Gottschlich S, Ambrosch P, Kramkowski D, Laudien M, Buchelt T, Gross WL, Hellmich B. Head and neck manifestations of Wegener’s granulomatosis. Rhinology 2006; 44: 227-233
• 11 Knopf A, Bas M, Chaker A, Strassen U, Pickhard A, Stark T, Lahmer T, Thürmel K. Rheumatic disorders affecting the head and neck: underestimated diseases. Rheumatology (Oxford) 2011; 50: 2029-3426
• 12 Iacovou E, Vlastarakos PV, Nikolopoulos TP. Laryngeal Involvement in Connective Tissue Disorders. Is it Important for Patient Management? Indian J. Otolaryngol Head Neck Surg 2014; 66 (Suppl 1): 22-29
• 13 Brooker DS. Rheumatoid arthritis: otorhinolaryngological manifestations. Clin Otolaryngol Allied Sci 1988; 13: 239-246
• 14 Voulgari PV, Papazisi D, Bai M, Zagorianakou P, Assimakopoulos D, Drosos AA. Laryngeal involvement in rheumatoid arthritis. Rheumatol Int 2005; 25: 321-325
• 15 Bayar N, Kara SA, Keleş I, Koç C, Altinok D, Orkun S. Cricoarytenoiditis in rheumatoid arthritis: radiologic and clinical study. J Otolaryngol 2003; 32: 373-378
• 16 Abdel-Aziz M, Azab NA, Bassyouni IH, Hamdy G. Laryngeal involvement in juvenile idiopathic arthritis patients. Clin Rheumatol 2011; 30: 1251-1256
• 17 Lawry GV, Finerman ML, Hanafee WN, Mancuso AA, Fan PT, Bluestone R. Laryngeal involvement in rheumatoid arthritis. A clinical, laryngoscopic and computerized tomographic study. Arthritis Rheum 1984; 27: 873-882
• 18 Speyer R, Speyer I, Heijnen MA. Prevalence and relative risk of dysphonia in rheumatoid arthritis. J Voice 2008; 22: 232-237
• 19 Kolman J, Morris I. Cricoarytenoid arthritis: a cause of acute upper airway obstruction in rheumatoid arthritis. Can J Anaesth 2002; 49: 729-732
• 20 Pathan EM, Oak JL, Jakareddy R, Sathe S, Kejriwal A. Upper airway obstruction due to cricoarytenoid arthritis in a case of systemic onset juvenile rheumatoid arthritis. J Assoc Physicians India 2001; 49: 566-567
• 21 Kamanli A, Gok U, Sahin S, Kaygusuz I, Ardicoglu O, Yalcin S. Bilateral cricoarytenoid joint involvement in rheumatoid arthritis: a case report. Rheumatology (Oxford) 2001; 40: 593-594
• 22 Eckel HE, Wittekindt C, Klussmann JP, Schroeder U, Sittel C. Management of bilateral arytenoid cartilage fixation versus recurrent laryngeal nerve paralysis. Ann Otol Rhinol Laryngol 2003; 112: 103-108
• 23 Sørensen WT, Møller-Andersen K, Behrendt N. Rheumatoid nodules of the larynx. J Laryngol Otol 1998; 112: 573-574
• 24 Teitel AD, MacKenzie CR, Stern R, Paget SA. Laryngeal involvement in systemic lupus erythematosus. Semin Arthritis Rheum 1992; 22: 203-214
• 25 Hilgert E, Toleti B, Kruger K, Nejedlo I. Hoarseness due to bamboo nodes in patients with autoimmune diseases: a review of literature. J Voice 2008; 22: 343-350
• 26 García MA, Alarcón GS, Boggio G, Hachuel L, Marcos AI, Marcos JC, Gentiletti S, Caeiro F, Sato EI, Borba EF, Brenol JC, Massardo L, Molina-Restrepo JF, Vásquez G, Guibert-Toledano M, Barile-Fabris L, Amigo MC, Huerta-Yáñez GF, Cucho-Venegas JM, Chacón-Diaz R, Pons-Estel BA. Primary cardiac disease in systemic lupus erythematosus patients: protective and risk factors – data from a multi-ethnic Latin American cohort. Rheumatology (Oxford) 2014; [Epub ahead of print]
• 27 Schwemmle C, Kreipe HH, Witte T, Ptok M. Bamboo nodes associated with mixed connective tissue disease as a cause of hoarseness. Rheumatol Int 2013; 33: 777-781
• 28 Cannady SB, Batra PS, Koening C, Lorenz RR, Citardi MJ, Langford C, Hoffman GS. Sinonasal Wegener granulomatosis: a single-institution experience with 120 cases. Laryngoscope 2009; 119: 757-761
• 29 Wittekindt C, Lüers JC, Drebber U, Guntinas-Lichius O, Hüttenbrink KB. ANCA-negative subglottic laryngeal stenosis in childhood. HNO 2007; 55: 807-811
• 30 Belostotsky VM, Shah V, Dillon MJ. Clinical features in 17 paediatric patients with Wegener granulomatosis. Pediatr Nephrol 2002; 17: 754-761
• 31 Blaivas AJ, Strauss W, Yudd M. Subglottic stenosis as a complication of Wegener’s granulomatosis. Prim Care Respir J 2008; 17: 114-116
• 32 Gluth MB, Shinners PA, Kasperbauer JL. Subglottic stenosis associated with Wegener’s granulomatosis. Laryngoscope 2003; 113: 1304-1307
• 33 Belloso A, Estrach C, Keith AO. Supraglottic stenosis in localized Wegener granulomatosis. Ear Nose Throat J 2008; 87: E11-E14
• 34 Morgenthau AS, Teirstein AS. Sarcoidosis of the upper and lower airways. Expert Rev Respir Med 2011; 5: 823-833
• 35 Schwartzbauer HR, Tami TA. Ear, nose, and throat manifestations of sarcoidosis. Otolaryngol Clin North Am 2003; 36: 673-684
• 36 Baughman RP, Lower EE, du Bois RM. Sarcoidosis. Lancet 2003; 29 : 1111-1118
• 37 Dean CM, Sataloff RT, Hawkshaw MJ, Pribikin E. Laryngeal sarcoidosis. J Voice 2002; 16: 283-288
• 38 Gallivan GJ, Landis JN. Sarcoidosis of the larynx: preserving and restoring airway and professional voice. J Voice 1993; 7: 81-94
• 39 Bower JS, Belen JE, Weg JG, Dantzker DR. Manifestations and treatment of laryngeal sarcoidosis. Am Rev Respir Dis 1980; 122: 325-332
• 40 Fortune S, Courey MS. Isolated laryngeal sarcoidosis. Otolaryngol Head Neck Surg 1998; 118: 868-870
• 41 James JC, Simpson CB. Treatment of laryngeal sarcoidosis with CO2 laser and mitomycin-C. Otolaryngol Head Neck Surg 2004; 130: 262-264
• 42 Neel 3rd HB, McDonald TJ. Laryngeal sarcoidosis: report of 13 patients. Ann Otol Rhinol Laryngol 1982; 91 (4 Pt 1): 359-362
• 43 Davis C, Girzadas Jr DV. Laryngeal sarcoidosis causing acute upper airway obstruction. Am J Emerg Med 2008; 26: 114.e1-114.e3
• 44 Yanardağ H, Enoz M, Papila I, Uygun S, Caner M, Karayel T. Upper respiratory tract involvement of sarcoidosis in the Turkish population. Otolaryngol Head Neck Surg 2006; 134: 848-851
• 45 Plaschke CC, Owen HH, Rasmussen N. Clinically isolated laryngeal sarcoidosis. Eur Arch Otorhinolaryngol 2011; 268: 575-804
• 46 Trentham DE, Le CH. Relapsing polychondritis. Ann Intern Med 1998; 129: 114-122
• 47 Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C. Relapsing polychondritis. Joint Bone Spine 2014; 81: 118-124
• 48 Kim CM, Kim BS, Cho KJ, Hong SJ. Laryngotracheal involvement of relapsing polychondritis in a Korean girl. Pediatr Pulmonol 2003; 35: 314-317
• 49 Woodbury K, Smith LJ. Relapsing polychondritis: a rare etiology of dysphonia and novel approach to treatment. Laryngoscope 2011; 121: 1006-1008
• 50 Karaiskaki N, Mann WJ. Subglottic tracheal stenosis. HNO 2012; 60: 505-510
• 51 Karaman E, Duman C, Cansz H, Ylmaz M, Ibrahimov M. Laryngotracheal reconstruction at relapsing polychondritis. J Craniofac Surg 2010; 21: 211-212
• 52 McAdam LP, O’Hanlan MA, Bluestone R, Pearson CM. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore) 1976; 55: 193-215
• 53 Fan YC, Li WG, Zheng MH, Gao W, Zhang YY, Song LJ. Invasive fungal infection in patients with systemic lupus erythematosus: experience from a single institute of Northern China. Gene 2012; 10 : 184-187
• 54 Bejar C, Basset-Seguin N, Faure F, Fieschi C, Frances C, Guenne C, Lebbe C, Peraldi MN, Roux J, Lamas G, Maubec E. SFORL workgroup . French ENT Society (SFORL) guidelines for the management of immunodeficient patients with head and neck cancer of cutaneous origin. Eur Ann Otorhinolaryngol Head Neck Dis 2014; 131: 121-129
• 55 Pickhard A, Smith E, Rottscholl R, Brosch S, Reiter R. Disorders of the larynx and chronic inflammatory diseases. Laryngorhinootologie 2012; 91: 758-756