An Aggressive Plasmablastic Lymphoma of the Oral Cavity as Primary Manifestation of Acquired Immunodeficiency Syndrome: Case Report and Literature Review

Marcelo Corti; Gonzalo Minué; Ana Campitelli; Marina Narbaitz; Leonardo Gilardi

doi:10.1055/s-0034-1397335

International Archives of Otorhinolaryngology, Table of Contents

Int Arch Otorhinolaryngol 2015; 19(04): 354-358
DOI: 10.1055/s-0034-1397335

Case Report

Thieme Publicações Ltda Rio de Janeiro, Brazil

An Aggressive Plasmablastic Lymphoma of the Oral Cavity as Primary Manifestation of Acquired Immunodeficiency Syndrome: Case Report and Literature Review

Marcelo Corti

¹Department of HIV/AIDS, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina

²Department of Internal Medicine, University of Buenos Aires School of Medicine, Paraguay, Buenos Aires, Argentina

,

Gonzalo Minué

³Department of Hematology Unit, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina

,

Ana Campitelli

⁴Histopathology Laboratory, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina

,

Marina Narbaitz

⁴Histopathology Laboratory, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina

,

Leonardo Gilardi

⁵Sociedad Iberoamericana de Información Científica, Buenos Aires, Argentina

› Author Affiliations

Abstract

Introduction Plasmablastic lymphoma is a rare entity that was first described in the jaws and the oral cavity of patients with human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). Plasmablastic lymphoma is considered as a diffuse, large, B-cell lymphoma with a unique phenotype and a predilection for the oral cavity.

Objective The authors describe a case of an aggressive plasmablastic lymphoma of the oral cavity as the primary manifestation of AIDS.

Resumed Report We report a case of plasmablastic lymphoma involving only the oral cavity as the first manifestation of AIDS. Diagnosis was confirmed by the oral lesion biopsy and the histopathologic examination that showed a dense infiltrate composed of atypical lymphocytes with numerous plasmocytes that expressed the plasma cell markers MUM-1 and CD138 and that were negative for the B-cell markers CD3, CD20, and CD45. Immunohistochemical and in situ hybridization revealed the Epstein-Barr virus genome in the atypical cells. Polymerase chain reaction was also positive for human herpesvirus-8 RNA.

Conclusion The HIV serologic status should be evaluated in all patients with plasmablastic lymphoma of the oral cavity or extraoral sites.

Keywords

plasmablastic lymphoma - oral cavity - HIV - AIDS

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References

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