NAFLD linked hepatic iron stores and impact of fat reducing agents on males and females Rattus norveicus

Dietary obesity leading to non alcoholic fatty liver disease (NAFLD) is also linked with hepatic iron overburden. This is the most prevalent hepatic disorder of developed countries. The current project was designed to observe the effect of the fat plummeting agents on NAFLD linked iron stores of body on the basis of gender. Males (M) and females (F) Rattus norveicus (n= 40) were further divided into four groups (n= 10) designated as 0, I, II and III. Group 0 served as negative control and was fed on 100% rat chow. Group I served as positive control and consumed HFD, group II and III were experimental groups and consumed HFD supplemented with 50 g Nigella sativa seeds or Plantago ovata husks respectively. The histological examination exhibited that elevated iron stores were present in livers of M-I, M-II, F-I and F-II groups while lower iron stores were present in the groups M-III and F-III. Taking together these findings it can be inferred that HFD causes the iron burden in both genders of Rattus norvegicus and P. ovata husk is potent to reduce the NAFLD linked hepatic iron stores.

Corresponding author: Abbas, Afshan S

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