Managing Hypertension by Polyphenols

Salvador Fernández-Arroyo; Jordi Camps; Javier A. Menendez; Jorge Joven

doi:10.1055/s-0034-1396310

Planta Medica, Inhaltsverzeichnis

Planta Med 2015; 81(08): 624-629
DOI: 10.1055/s-0034-1396310

Reviews

Georg Thieme Verlag KG Stuttgart · New York

Managing Hypertension by Polyphenols

Authors

Salvador Fernández-Arroyo

¹Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut dʼInvestigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Campus of International excellence Southern Catalonia, Reus, Spain
Jordi Camps

¹Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut dʼInvestigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Campus of International excellence Southern Catalonia, Reus, Spain
Javier A. Menendez

²Metabolism and Cancer Group, Translational Research Laboratory, Catalan Institute of Oncology-Girona, Molecular Oncology, Girona Biomedical Research Institute, Girona, Spain
Jorge Joven

¹Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut dʼInvestigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Campus of International excellence Southern Catalonia, Reus, Spain

Abstract

Some polyphenols, obtained from plants of broad use, induce a favorable endothelial response in hypertension and beneficial effects in the management of other metabolic cardiovascular risks. Previous studies in our laboratories using the calyces of Hibiscus sabdariffa as a source of polyphenols show that significant effects on hypertension are noticeable in humans only when provided in high amounts. Available data are suggestive in animal models and ex vivo experiments, but data in humans are difficult to acquire. Additionally, and despite the low bioavailability of polyphenols, intervention studies provide evidence for the protective effects of secondary plant metabolites. Assumptions on public health benefits are limited by the lack of scientific knowledge, robust data derived from large randomized clinical trials, and an accurate assessment of the bioactive components provided by common foodstuff. Because it is likely that clinical effects are the result of multiple interactions among different polyphenols rather than the isolated action of unique compounds, to provide polyphenol-rich botanical extracts as dietary supplements is a suggestive option. Unfortunately, the lack of patent perspectives for the pharmaceutical industries and the high cost of production and release for alimentary industries will hamper the performance of the necessary clinical trials. Here we briefly discuss whether and how such limitations may complicate the extensive use of plant-derived products in the management of hypertension and which steps are the necessary to deal with the predictable complexity in a possible clinical practice.

Key words

Hibiscus sabdariffa - Malvaceae - botanical extracts - cardiovascular risk - hypertension - oxidation - metabolism - polyphenols

Volltext

Referenzen

References
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