Deutsche Zeitschrift für Onkologie 2015; 47(01): 10-12
DOI: 10.1055/s-0034-1395854
© Karl F. Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Grüner Tee zur primären und tertiären Prophylaxe des Mammakarzinoms

Karsten Münstedt
Heidrun Männle
Further Information

Publication History

Publication Date:
09 April 2015 (online)


Grüner Tee ist ein Getränk mit vielen gesundheitlich interessanten Inhaltsstoffen. In präklinischen Untersuchungen haben diese Wirkungen gezeigt, die bei der Entstehung von malignen Prozessen relevant sein könnten. Zahlreiche Studien haben Hinweise für eine präventive Wirkung von grünem Tee bei einer Vielzahl von Tumorentitäten ergeben, unter anderem auch beim Mammakarzinom. Hier liegen Metaanalysen zur primären und tertiären Prävention vor. Da grüner Tee sich überdies positiv auf den Glukose- und Fettstoffwechsel auswirkt und selten zu unerwünschten Wirkungen führt, ist grüner Tee damit eine der interessanteren Substanzen im Bereich der komplementären Behandlung des Mammakarzinoms, die eine weitere intensive Erforschung verdient. Grüner Tee ist auch eine Methode, die Patientinnen mit dem Wunsch nach ergänzender Behandlung mit am ehesten empfohlen werden kann.


Green tea is a beverage with many interesting compounds which may positively affect health. Preclinical investigations have shown effects with relevance to cancer incidence. Numerous studies revealed evidence for these preventive effects in various tumor entities, among those also breast cancer. Meanwhile there are meta-analyses on primary and tertiary prevention. Since green tea also exerts positive effects on glucose and fat metabolism and rarely leads to significant side effects, green tea may be considered to be one of the most interesting substances in the complementary treatment of breast cancer. Thus it clearly deserves more intensive scientific investigation but since evidence is much better compared to other complementary methods it may be recommended to patients who ask for additional treatment options.

  • Literatur

  • 1 Abd El-Aty AM, Choi JH, Rahman MM et al. Residues and contaminants in tea and tea infusions: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2014; 31: 1794-1804
  • 2 Boehm K, Borrelli F, Ernst E et al. Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database Syst Rev 2009; 3: CD005004
  • 3 Di Lorenzo C, Ceschi A, Kupferschmidt H et al. Adverse Effects of Plant Food Supplements and Botanical Preparations: A Systematic Review with Critical Evaluation of Causality. Br J Clin Pharmacol 2014; Sept 24. DOI: 10.1111/bcp.12519.
  • 4 Eddy SF, Kane SE, Sonenshein GE. Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate. Cancer Res 2007; 67: 9018-9023
  • 5 Fon Sing M, Yang WS, Gao S et al. Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis. Eur J Cancer Prev 2011; 20: 157-165
  • 6 Gao M, Ma W, Chen XB et al. Meta-analysis of green tea drinking and the prevalence of gynecological tumors in women. Asia Pac J Public Health 2013; 25 (4 Suppl): 43-48
  • 7 Hartley L, Flowers N, Holmes J et al. Green and black tea for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2013; 6: CD009934
  • 8 Hu L, Miao W, Loignon M et al. Putative chemopreventive molecules can increase Nrf2-regulated cell defense in some human cancer cell lines, resulting in resistance to common cytotoxic therapies. Cancer Chemother Pharmacol 2010; 66: 467-474
  • 9 Imai K, Suga K, Nakachi K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev Med 1997; 26: 769-775
  • 10 Jurgens TM, Whelan AM, Killian L et al. Green tea for weight loss and weight maintenance in overweight or obese adults. Cochrane Database Syst Rev 2012; 12: CD008650
  • 11 Kim A, Chiu A, Barone MK et al. Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis. J Am Diet Assoc 2011; 111: 1720-1729
  • 12 Li MJ, Yin YC, Wang J, Jiang YF. Green tea compounds in breast cancer prevention and treatment. World J Clin Oncol 2014; 5: 520-528
  • 13 Li Y, Yuan YY, Meeran SM, Tollefsbol TO. Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. Mol Cancer 2010; 9: 274
  • 14 Lin YW, Hu ZH, Wang X et al. Tea consumption and prostate cancer: an updated meta-analysis. World J Surg Oncol 2014; 12: 38
  • 15 Liu K, Zhou R, Wang B et al. Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials. Am J Clin Nutr 2013; 98: 340-348
  • 16 Luo T, Wang J, Yin Y et al. Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma. Breast Cancer Res 2010; 12: R8-
  • 17 Myung SK, Bae WK, Oh SM et al. Green tea consumption and risk of stomach cancer: a meta-analysis of epidemiologic studies. Int J Cancer 2009; 124: 670-677
  • 18 Ogunleye AA, Xue F, Michels KB. Green tea consumption and breast cancer risk or recurrence: a meta-analysis. Breast Cancer Res Treat 2010; 119: 477-484
  • 19 Sang LX, Chang B, Li XH, Jiang M. Green tea consumption and risk of esophageal cancer: a meta-analysis of published epidemiological studies. Nutr Cancer 2013; 65: 802-812
  • 20 Sartippour MR, Pietras R, Marquez-Garban DC et al. The combination of green tea and tamoxifen is effective against breast cancer. Carcinogenesis 2006; 27: 2424-2433
  • 21 Seely D, Mills EJ, Wu P et al. The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review and metaanalysis. Integr Cancer Ther 2005; 4: 144-155
  • 22 Sun CL, Yuan JM, Koh WP, Yu MC. Green tea, black tea and breast cancer risk: a meta-analysis of epidemiological studies. Carcinogenesis 2006; 27: 1310-1315
  • 23 Tang NP, Li H, Qiu YL et al. Tea consumption and risk of endometrial cancer: a metaanalysis. Am J Obstet Gynecol 2009; 201 605.e1–8
  • 24 Wang Y, Yu X, Wu Y, Zhang D. Coffee and tea consumption and risk of lung cancer: a dose-response analysis of observational studies. Lung Cancer 2012; 78: 169-170
  • 25 Wang ZH, Gao QY, Fang JY. Green tea and incidence of colorectal cancer: evidence from prospective cohort studies. Nutr Cancer 2012; 64: 1143-1152
  • 26 Wu S, Li F, Huang X et al. The association of tea consumption with bladder cancer risk: a meta-analysis. Asia Pac J Clin Nutr 2013; 22: 128-137
  • 27 Zhang S, Shan L, Li Q et al. Systematic analysis of the multiple bioactivities of green tea through a network pharmacology approach. Evid Based Complement Alternat Med 2014; 512081. DOI: 10.1155/2014/512081.