Planta Med 2014; 80 - LP32
DOI: 10.1055/s-0034-1395088

Evaluation of antimicrobial activity of some compounds isolated from Rhamnus cathartica L.

M Hamed 1, L Refahy 1, M Abdel-Aziz 2
  • 1Medicinal chemistry department, Theodor Bilharz Research Institute, Giza, Egypt
  • 2Department of Microbial Chemistry, National Research Center, Dokki, Cairo, Egypt

A new anthraquinone derivative, 1,8-dihydroxy-2-[(Z)-4-methylpenta-1,3-dien-1-yl] anthraquinone (1), together with known anthraquinone compounds identified as 2-acetyl-3,8-dihydroxy-6-methoxy-anthraquinone (2), emodin (3), glucofrangulin A (4) and a phenanthrene derivative named dendrochrysanene (5), the lactones β-sorigenin (6) and geshoidin (7), the xanthone pruniflorone H (8), the oxanthrone rumejaposide I (9), and the flavonols kaempferol (10) and quercetin (11) have been isolated from the methanolic extract of R. cathartica L. All isolated compounds were subjected to antimicrobial activity testing; compounds (1), (3) and (9) exhibited antibacterial [G+ve, G-ve] and anti-yeast activity, whereas compounds (5) and (11) exhibited only antibacterial activity [G+ve and G-ve]. Compounds (2), (4), (7) and (10) exhibited antibacterial activity [G-ve], while compounds (6) and (8) exhibited antibacterial [G-ve] and anti-yeast activity. The structure of the isolated compounds was confirmed by detailed analysis of their 1 H-, 13C-NMR, mass spectral data and by the results of hydrolytic cleavage.

Keywords: Plant extract, Rhamnus cathartica L., antimicrobial activity, flavonol

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