Planta Med 2014; 80 - LP23
DOI: 10.1055/s-0034-1395081

New phenolic glycosides from Citrillus lanatus with radical scavenging properties

A Adebayo 1, 2, FH Song 2, XT Liu 2, HQ Dai 2, H Pei 2, JY Zhang 2, LX Zhang 2
  • 1Department of Biological Sciences, College of Science and Technology, Covenant University, PMB 1023, Canaan land, Ota, Ogun State, Nigeria
  • 2CAS Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

Three new compounds (1 – 3) were isolated from the whole plant of Citrullus lanatus (Cucurbitaceae). The structures of these compounds were characterized by MS, IR, 1D and 2D NMR. The DPPH radical scavenging property of these compounds as well as vitamin C which served as the positive control group was determined. The result showed that Compound 3 exhibited the highest scavenging activity with an EC50 value of 0.34 mM while Compounds 1 and 2 showed scavenging activity of 0.52 and 5.37 mM respectively. The EC50 value for vitamin C is 1.36 mM. The result therefore showed that Compounds 1 and 2 possess better scavenging property than vitamin C and thus may serve as potent antioxidant drugs in oxidative stress management.

Keywords: Citrullus lanatus, Cucurbitaceae, Phenolic glycosides, scavenging properties