Planta Med 2014; 80 - P2B106
DOI: 10.1055/s-0034-1394983

Trypanocidal activity evaluation of Distictella mansoana (DC.) Bureau and Stizophyllum perforatum (Cham.) Miers extracts

FAJ Silva 1, AA Nakaima Kohatsu 1, LO Regasini 3, MC Marx Young 4, VS Bolzani 2, DH Siqueira Silva 2, RM Barretto Cicarelli 1
  • 1Universidade Estadual Paulista “Júlio de Mesquita Filho”, Biological Sciences Department, Brazil
  • 2Universidade Estadual Paulista “Júlio de Mesquita Filho”, NuBBE-Institute of Chemistry, Brazil
  • 3Universidade Estadual Paulista “Júlio de Mesquita Filho”, Chemistry and Environmental Sciences Department, Brazil
  • 4Botanical Institute of São Paulo, Environment Department, Center for Research in Physiology and Biochemistry, Brazil

Chagas disease is caused by protozoan Trypanosoma cruzi and transmitted by insect blood-sucking triatomine bug. Chagas disease is a neglected disease and endemic in Latin America [1]. Currently only two drugs are prescribed, nifurtimox and benznidazole, which are more efficient during the acute phase, but with undesirable effects collateral, even many research has been undergoing to select another better compound. Resistant strains to these medicines decreases the rate of cure [2]. Our laboratory in collaboration with NuBBE [3] tested more than 1,000 natural products from plants against epimastigote forms of T. cruzi (Y strain) since 2008. In the present study we performed in vitro biological assay [4] with crude extracts from leaves of Bignoniaceae, Distictella mansoana and Stizophyllum perforatum. The values of IC50 obtained were 30,4 and 20,2 µg/mL, respectively. Benznidazole IC50 was 9,01 µg/mL as positive control. Bignoniaceae family contains naphtoquinones with trypanocidal activity. Therefore the results obtained showed that some promising compounds present in the extracts can be investigated in attempt to isolate the active(s) substance(s) in searching of less toxic and more effective medicine.

Acknowledgements: Fapesp for the financial support.

Keywords: Distictella mansoana, Stizophyllum perforatum, extracts, Bignoniaceae, Chagas disease, Trypanosoma cruzi

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