Planta Med 2014; 80 - P1L162
DOI: 10.1055/s-0034-1394819

New antibacterial compounds from plant biodiversity

A Kerdudo 1, V Gonot 1, EN Ellong 2, K Rochefort 2, L Boyer 3, 4, T Michel 1, X Fernandez 1
  • 1Université Nice Sophia Antipolis, ICN, UMR CNRS 7272, Parc Valrose, 06108 Nice CEDEX 2, France
  • 2Pôle Agroalimentaire Régional de Martinique, Habitation Petit-Morne, 97231 Lamentin Martinique, France
  • 3INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire (C3 M), Nice, France
  • 4Université de Nice-Sophia-Antipolis, UFR Médecine, Nice, France

The increasing incidence of drug-resistant pathogens and the replacement of toxic preservative have drawn the attention of the pharmaceutical and cosmetic communities towards studies on the potential antimicrobial activity of plant-derived substances [1 – 2]. For instance, recent reports have confirmed the potential of essential oils as antimicrobial agents [3 – 4]. This poster presents recent findings in antibacterial natural compounds that have been undergone in our laboratory. A first work aimed to identify new promising plant sources which could be exploited as cosmetic preservatives as alternative to questionable parabens. A total of 50 plants from PACA region (south east France) were selected based on ethnobotanical and ethnopharmacological studies for screening against five pathogens. Santolina chamaecyparissus L. (cotton lavender, Asteraceae) appeared to be the most interesting plant species with high antimicrobial and antioxidant effects and low toxicity. After extraction optimization, a spiroether derivative was isolated and identified as the bioactive molecule. Our antimicrobial approach has been displayed through two studies on plants from Martinique Island. For instance, the volatile constituents obtained from the essential oil of the aerial parts of Petiveria alliacea L. were examined by a combination of GC/FID and GC-MS techniques. A total of 53 components representing 86.3 to 97.0% of the essential total GC/FID chromatogram were identified, among them 41 molecules were for the first time described in P. alliacea oils. The most abundant compounds were toluenethiol, phytol, dibenzyldisulfide and benzaldehyde. Furthermore, in-vitro bioevaluation showed that P. alliacea oil was active against several microorganisms including a methicillin-resistant Staphylococcus aureus strain.

Keywords: Antimicrobial, Medicinal plants, Petiveria alliacea, GC-MS

References:

[1] Cowan, MM (1999) Clin Microbiol Rev 12: 564 – 582.

[2] Radulović et al. (2013) Curr Med Chem 20: 932 – 52.

[3] Ramos-Alveranga et al. (2014)J Nat Prod 77: 603 – 610.

[4] Seow et al. (2014) Crit Rev Food Sci Nutr 54: 625 – 644.