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DOI: 10.1055/s-0034-1394721
New phenolic glycosides from the twigs of Salix glandulosa
The genus Salix (Salicaceae) has about 400 species of deciduous trees and shrubs. Several species in this genus have been used as Korean folk medicine for the treatment of hypertension, cough, toothache, burns and furuncle. Previous phytochemical investigations on genus Salix reported phenolic compounds, flavonoids, tannins, terpenes and lignans, and their cytotoxic, anti-inflammatory and antibacterial activities. However, few phytochemical and biological investigations on Salix glandulosa Seemen have been performed. An extended phytochemical investigation of the twigs of S. glandulosa afforded twelve new phenolic glycosides, glanduloidin A-L (1-12), and a known one (13). The structures of the new compounds (1-12) were characterized by extensive NMR methods (1H and 13C NMR, 1H-1H COSY, HMQC and HMBC), chemical hydrolysis and GC/MS. The absolute configuration of known compound 13 was determined in this study. All the isolates (1-13) were tested for their inhibitory effects on NO production in a LPS-activated murine microglial cells and their effects on nerve growth factor (NGF) secretion from C6 glioma cells.
Keywords: Salix glandulosa, Salicaceae, phenolic glycosides, NO, NGF