Planta Med 2014; 80 - P1C21
DOI: 10.1055/s-0034-1394646

Antinociceptive and anti-inflammatory activities of Elsholtzia ciliata (Thunb.) Hyl. (Lamiaceae) extracts

Q Zhang 1, CC Guilhon 2, PD Fernandes 2, F Boylan 1
  • 1School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
  • 2Laboratory of Pharmacology of Pain and Inflammation, Institute of Biomedical Science, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho 373, J10. Rio de Janeiro, Brazil

Introduction: Elsholtzia ciliata (Thunb.) Hyl. (Lamiaceae), is an important Traditional Chinese Medicine (TCM). It has been used to treat a range of diseases such as colds, fevers and oedema for thousands of years [1].

Aim of the study: To evaluate antinociceptive and anti-inflammatory activities of the extracts.

Materials and method: The plant was identified and deposited in the herbarium of the China Pharmaceutical University under the number CPU-2013101802. A crude ethanol (CE) extract and its fractions in hexane (HEX), dichloromethane (DCM) and n-butanol (NBU) were prepared. Extract and fractions were submitted to the formalin test. Acetyl salicylic acid (ASA) was used as positive control.

Results:

Tab. 1: Effect of the extract and fractions.

Group

Dose (mg/kg)

Early phase (seconds)

Late phase (seconds)

P value

Control

-

59.23 ± 7.46

316.00 ± 50.00

-

ASA

100

42.04 ± 5.29

238.59 ± 46.15

-

CE

100

56.50 ± 13.11

199.00 ± 55.79*

0.0034

HEX

100

36.35 ± 14.86*

355.40 ± 130.00

0.0050

DCM

100

53.74 ± 13.88

198.00 ± 27.72*

0.0011

NBU

10

37.98 ± 4.66**

397.00 ± 93.70

0.0002

NBU

30

34.68 ± 9.89**

259.20 ± 46.76

0.0006

The results were presented as mean ± S.D. (n = 5) of licking time. *p < 0.01 significantly difference compared with the control group. **p < 0.001 significantly difference compared with the control group.

Conclusion: This study strongly proved this plant's antinociceptive and anti-inflammatory potential being this is an important finding as this plant is widely used as an anti-inflammatory TCM in China.

Keywords: Traditional Chinese Medicine, Ethnomedicine, Anti-inflammatory, Antinociceptive, Pharmacology, Formalin

References:

1. A. L. Liu et al. (2007) J.Chin.Pharm.Sci 16:73 – 78