Wound healing activity of geraniin and aqueous leaf extract of Phyllanthus muellerianus (Kuntze) Excel (Euphorbiaceae)

YD Boakye; C Agyare; PG Ayande; EA Asiamah; NA Titiloye

doi:10.1055/s-0034-1394561

Planta Medica, Inhaltsverzeichnis

Wound healing activity of geraniin and aqueous leaf extract of Phyllanthus muellerianus (Kuntze) Excel (Euphorbiaceae)

YD Boakye ¹, C Agyare ¹, PG Ayande ², EA Asiamah ³, NA Titiloye ³

¹Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
²Department of Human Biology and Nursing, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana
³Department of Pathology, Komfo Anokye Teaching Hospital, Kumasi, Ghana

Abstract

Introduction: In recent times, there has been an increase in the incidence of wounds with a proportionate increase in various abnormalities of the healing process. This has necessitated research into agents that can enhance the healing process hence the selection of Phyllanthus muellerianus, a wound healing promoter [1, 2].

Aim: To determine the wound healing properties of aqueous leaf extract of P. muellerianus (ALEPM) and its isolate, geraniin.

Method: Excision wound model was used and wound area contraction determined. Excised skin tissues were assessed for breaking strength, hydroxyproline content, histopathological and immunohistochemistry studies [2].

Results: There was significant (p < 0.001) increase in wound contraction (Fig. 1) in the ALEPM and geraniin treated groups and profuse angiogenesis, enhanced collagenation and re-epithelialization in treated tissues compared with the untreated. The content of hydroxyproline in treated tissues was found to be dose-dependent.

Conclusion: ALEPM and geraniin exhibited wound healing properties.

References:

[1] Agyare et al., (2011). Phytomedicine, 18(7): 617 – 24.

[2] Boakye and Agyare, (2013). Planta Med. 79:1161 – 1162.

[3] Tang et al., (2007). Eur. J. Pharmacol. 567:177 – 185.