Endosc Int Open 2015; 03(01): E91-E98
DOI: 10.1055/s-0034-1390747
Original article
© Georg Thieme Verlag KG Stuttgart · New York

Management of post-cholecystectomy biliary fistula according to type of cholecystectomy

Ahmad M. Sultan
Gastro-enterology Surgical Center, Surgery Department, Mansoura University, Mansoura, Egypt
,
Ayman M. Elnakeeb
Gastro-enterology Surgical Center, Surgery Department, Mansoura University, Mansoura, Egypt
,
Mohamed M. Elshobary
Gastro-enterology Surgical Center, Surgery Department, Mansoura University, Mansoura, Egypt
,
Ahmed A. El-Geidi
Gastro-enterology Surgical Center, Surgery Department, Mansoura University, Mansoura, Egypt
,
Tarek Salah
Gastro-enterology Surgical Center, Surgery Department, Mansoura University, Mansoura, Egypt
,
Ehab A. El-hanafy
Gastro-enterology Surgical Center, Surgery Department, Mansoura University, Mansoura, Egypt
,
Ehab Atif
Gastro-enterology Surgical Center, Surgery Department, Mansoura University, Mansoura, Egypt
,
Emad Hamdy
Gastro-enterology Surgical Center, Surgery Department, Mansoura University, Mansoura, Egypt
,
Gamal K. Elebiedy
Gastro-enterology Surgical Center, Surgery Department, Mansoura University, Mansoura, Egypt
› Author Affiliations
Further Information

Publication History

submitted 24 April 2014

accepted after revision 08 September 2014

Publication Date:
24 October 2014 (online)

Background and study aims: A study was undertaken to describe the management of post-cholecystectomy biliary fistula according to the type of cholecystectomy.

Patients and methods: A retrospective analysis of 111 patients was undertaken. They were divided into open cholecystectomy (OC) and laparoscopic cholecystectomy (LC) groups.

Results: Of the 111 patients, 38 (34.2 %) underwent LC and 73 (65.8 %) underwent OC. Endoscopic retrograde cholangiopancreatography (ERCP) diagnosed major bile duct injury (BDI) in 27 patients (38.6 %) in the OC group and in 3 patients (7.9 %) in the LC group (P = 0.001). Endoscopic management was not feasible in 15 patients (13.5 %) because of failed cannulation (n = 3) or complete ligation of the common bile duct (n = 12). Endoscopic therapy stopped leakage in 35 patients (92.1 %) and 58 patients (82.9 %) following LC and OC, respectively, after the exclusion of 3 patients in whom cannulation failed (P = 0 0.150). Major BDI was more commonly detected after OC (P < 0.001). Leakage was controlled endoscopically in 77 patients (98.7 %) with minor BDI and in 16 patients (53.3 %) with major BDI (P < 0.001).

Conclusions: Major BDI is more common in patients presenting with bile leakage after OC. ERCP is the first-choice treatment for minor BDI. Surgery plays an important role in major BDI. Magnetic resonance cholangiopancreatogrphy (MRCP) should be used before ERCP in patients with bile leakage following OC or converted LC.

 
  • References

  • 1 Fathy O, Wahab MA, Hamdy E et al. Post-cholecystectomy biliary injuries: one center experience. Hepatogastroenterology 2011; 58: 719-724
  • 2 Lau WY, Lai EC. Classification of iatrogenic bile duct injury. Hepatobiliary Pancreat Dis Int 2007; 6: 459-463
  • 3 Ryan ME, Geenen JE, Lehman GA et al. Endoscopic intervention for biliary leaks after laparoscopic cholecystectomy: a multicenter review. Gastrointest Endosc 1998; 47: 261-266
  • 4 Strasberg SM, Hertl M, Soper NJ. An analysis of the problem of biliary injury during laparoscopic cholecystectomy. J Am Coll Surg 1995; 180: 101-125
  • 5 Bergman JJ, van den Brink GR, Rauws EA et al. Treatment of bile duct lesions after laparoscopic cholecystectomy. Gut 1996; 38: 141-147
  • 6 Neuhaus P, Schmidt SC, Hintze RE et al. Classification and treatment of bile duct injuries after laparoscopic cholecystectomy [in German]. Chirurg 2000; 71: 166-173
  • 7 Singh V, Singh G, Verma GR et al. Endoscopic management of postcholecystectomy biliary leakage. Hepatobiliary Pancreat Dis Int 2010; 9: 409-413
  • 8 Hii MW, Gyorki DE, Sakata K et al. Endoscopic management of post-cholecystectomy biliary fistula. HPB (Oxford) 2011; 13: 699-705
  • 9 Fatima J, Barton JG, Grotz TE et al. Is there a role for endoscopic therapy as a definitive treatment for post-laparoscopic bile duct injuries?. J Am Coll Surg 2010; 211: 495-502
  • 10 Murr MM, Gigot JF, Nagorney DM et al. Long-term results of biliary reconstruction after laparoscopic bile duct injuries. Arch Surg 1999; 134: 604-609 ; discussion 609 – 610
  • 11 Lubikowski J, Post M, Bialek A et al. Surgical management and outcome of bile duct injuries following cholecystectomy: a single-center experience. Langenbecks Arch Surg 2011; 396: 699-707
  • 12 Trondsen E, Ruud TE, Nilsen BH et al. Complications during the introduction of laparoscopic cholecystectomy in Norway. A prospective multicentre study in seven hospitals. Eur J Surg 1994; 160: 145-151
  • 13 Barkun AN, Rezieg M, Mehta SN et al. Postcholecystectomy biliary leaks in the laparoscopic era: risk factors, presentation, and management. McGill Gallstone Treatment Group. Gastrointest Endosc 1997; 45: 277-282
  • 14 Rauws EA, Gouma DJ. Endoscopic and surgical management of bile duct injury after laparoscopic cholecystectomy. Best Pract Res Clin Gastroenterol 2004; 18: 829-846
  • 15 Ahmad F, Saunders RN, Lloyd GM et al. An algorithm for the management of bile leak following laparoscopic cholecystectomy. Ann R Coll Surg Engl 2007; 89: 51-56
  • 16 Ghazanfar S, Qureshi S, Leghari A et al. Endoscopic management of postoperative bile duct injuries. J Pak Med Assoc 2012; 62: 257-262
  • 17 Adamsen S, Hansen OH, Funch-Jensen P et al. Bile duct injury during laparoscopic cholecystectomy: a prospective nationwide series. J Am Coll Surg 1997; 184: 571-578
  • 18 Flum DR, Cheadle A, Prela C et al. Bile duct injury during cholecystectomy and survival in medicare beneficiaries. JAMA 2003; 290: 2168-2173
  • 19 Kaffes AJ, Hourigan L, De Luca N et al. Impact of endoscopic intervention in 100 patients with suspected postcholecystectomy bile leak. Gastrointest Endosc 2005; 61: 269-275
  • 20 Karvonen J, Gullichsen R, Laine S et al. Bile duct injuries during laparoscopic cholecystectomy: primary and long-term results from a single institution. Surg Endosc 2007; 21: 1069-1073
  • 21 Khalid TR, Casillas VJ, Montalvo BM et al. Using MR cholangiopancreatography to evaluate iatrogenic bile duct injury. AJR Am J Roentgenol 2001; 177: 1347-1352
  • 22 Singh VK, Khashab MA, Okolo 3rd PI et al. ERCP or laparoscopic exploration for the treatment of suspected choledocholithiasis?. Arch Surg 2010; 145: 796 ; author reply 796