Risks and Benefits of Carnitine Supplementation in Diabetes

M. Dambrova; E. Liepinsh

doi:10.1055/s-0034-1390481

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2015; 123(02): 95-100
DOI: 10.1055/s-0034-1390481

Mini-Review

Risks and Benefits of Carnitine Supplementation in Diabetes

M. Dambrova

¹Latvian Institute of Organic Synthesis, Riga, Latvia

,

E. Liepinsh

¹Latvian Institute of Organic Synthesis, Riga, Latvia

› Author Affiliations

Abstract

L-carnitine is a very popular food supplement due to its safety profile, antioxidant-type activity and suggested effects on energy metabolism pathways. L-carnitine participates in both fatty acid transport pathways and the export of acetyl groups out of the mitochondria. However, contradictory data exist concerning the pharmacological outcomes of L-carnitine treatment in diabetes mellitus, which is a highly prevalent metabolic disease characterised by hyperglycemia and associated with severe complications, including cardiovascular disease and dyslipidemia. Recently, the L-carnitine-derived metabolites, acylcarnitines and trimethylamine-N-oxide, have been associated with increased cardio-metabolic risks. This review aims to highlight the possible risks and benefits of L-carnitine supplementation.

Key words

L-carnitine - diabetes - food supplement

Full Text

References

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