Semin Neurol 2014; 34(04): 395-404
DOI: 10.1055/s-0034-1390388
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

IgG4-Related Disease and Other Causes of Inflammatory Meningeal Disease

Robert Carruthers
1  Department of Neurology, Brigham and Women's Hospital, Brookline, Massachusetts
Mollie Carruthers
2  Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts
Emanuel Della-Torre
3  Department of Medicine and Clinical Immunology, IRCCS-San Raffaele Scientific Institute, Milan, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
04 November 2014 (online)


Immunoglobulin-4 (IgG4-) related disease is a newly described treatable condition that has recently expanded the differential diagnosis of inflammatory meningeal disorders. This review will discuss the main clinical and pathophysiological features of IgG4-related meningeal disease in the context of meningeal inflammatory disorders in general. Particular attention will be dedicated to the differential diagnosis and the different therapeutic approaches.