Introduction T-cell lymphoma/Natural Killer Extranodal and Dendritic Cell Leukemia: A Case Report
Introduction: T-cell lymphoma/natural killer (NK) extranodal and dendritic cell leukemia (DCL) are rare neoplasms, representing less than 1% lymphomas and acute leukemias, respectively.
Objective: This study aims to report a rare case of DCL and NK extranodal lymphoma.
Resumed Report: A 32-year-old female patient presented with yellowish rhinorrhea, nasal congestion, and epistaxis for 3 months. Nasofibroscopy and computed tomography revealed tumoral lesion in topography of middle turbinate and one-third middle meatus. Nasopharynx was free. The tumor was removed and the histopathology revealed non-Hodgkin lymphoma with diffuse pattern. Immunohistochemistry demonstrated antigens CD3, CD5, CD20, CD45R0, and CD56 positive. After 2 years of monitoring, the patient required chemotherapy sessions due to metastasis, but without nasal recurrence. Recently, during hospitalization for febrile neutropenia, leukemia dendritic cells were diagnosed.
Conclusion: Around 75% of cases of nasal lymphoma are derivatives of T-cells and the expression of CD 56 defines the T/NK-cell lymphoma, while DCLs are unknown etiology, but they seem to be related also to tumors of NK cells.