Int Arch Otorhinolaryngol 2014; 18 - a2511
DOI: 10.1055/s-0034-1388945

Introduction T-cell lymphoma/Natural Killer Extranodal and Dendritic Cell Leukemia: A Case Report

Ana Lívia Muniz da Silva 1, Camila Lira Holanda de Lima Barros 1, Erica Carla Figuêiredo de Souza 1, José Diogo Rijo Cavalcante 1, Paloma Simoni Gama Ferreira 1, Samuel Neiva Almino 1
  • 1Hospital do Servidor Publico Municipal

Introduction: T-cell lymphoma/natural killer (NK) extranodal and dendritic cell leukemia (DCL) are rare neoplasms, representing less than 1% lymphomas and acute leukemias, respectively.

Objective: This study aims to report a rare case of DCL and NK extranodal lymphoma.

Resumed Report: A 32-year-old female patient presented with yellowish rhinorrhea, nasal congestion, and epistaxis for 3 months. Nasofibroscopy and computed tomography revealed tumoral lesion in topography of middle turbinate and one-third middle meatus. Nasopharynx was free. The tumor was removed and the histopathology revealed non-Hodgkin lymphoma with diffuse pattern. Immunohistochemistry demonstrated antigens CD3, CD5, CD20, CD45R0, and CD56 positive. After 2 years of monitoring, the patient required chemotherapy sessions due to metastasis, but without nasal recurrence. Recently, during hospitalization for febrile neutropenia, leukemia dendritic cells were diagnosed.

Conclusion: Around 75% of cases of nasal lymphoma are derivatives of T-cells and the expression of CD 56 defines the T/NK-cell lymphoma, while DCLs are unknown etiology, but they seem to be related also to tumors of NK cells.