Hepatic Metastases in Medullary Thyroid Carcinoma

Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor of the parafollicular cells or C type of the thyroid gland, mainly characterized by the production of calcitonin. The diagnosis of CMT can be accomplished by cytology samples of thyroid tissue obtained by needle aspiration, fine needle biopsy, but the gold standard is the pathological study of the piece. The main form of treatment is surgical and the main route is the lymphatic spread, and rarely spread to other locations. The case report in question comes from a patient with MTC, presented with calcitonin 777.00 and cervical lymphadenectomy, who was previously operated in another center (total thyroidectomy). The patient underwent modified neck dissection (I-IV right and left II-VI). The patient remained with undetectable calcitonin for 6 months, when it increased up to get 9,654 ng/mL over a period of 2 months. When screening positron emission tomography computed tomography scan, it was evidenced liver metastases, which showed spontaneous regression with chemotherapy with adriamicina. The case in question is of an unusual case thyroid carcinoma with liver metastasis, calling attention to the rarity of the case and its good response to chemotherapy.

Keywords: Metastasis, medullary carcinoma, thyroid, adriamicina.