Int Arch Otorhinolaryngol 2014; 18 - a2231
DOI: 10.1055/s-0034-1388863

Oral Manifestation of Non-Hodgkin Diffuse Large B-Cell Lymphoma

Douglas Antonio de Resende Gonçalves 1, João Machado Barreto de Menezes Neto 1, Juliana Pontes Andrade dos Santos 1, Marcelo Braz Vieira 1, Mariana Lima de Freitas 1, Raimundo Aldemar Silva Filho 1
  • 1Hospital das Forças Armadas-Brasília/DF, Brasília, Brazil
  • 2Clínica de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço

Introduction: The B-cell lymphoma affects about 90% of all cases of lymphoma. Diffuse large B-cell lymphoma is the most common form of non-Hodgkin lymphoma and mostly affects adults. The oral cavity constitutes approximately 2% of all non-Hodgkin lymphomas. The signs and symptoms of lymphoma in the oral cavity are of short duration and rapid progression of the lesion. The oral lesions are related to disease already widespread and rarely have their first appearance in the oral cavity.

Objectives: This study report a case of non-Hodgkin lymphoma with oral manifestation.

Resumed Report: A 51-year-old male patient was attended in the Service of Otorhinolaryngology of Hospital of the Armed Forces, Brasilia, on the reason for the appearance of lesion in the oral cavity for 40 days with no other associated complaints. On physical examination, there was bulging smooth surface in right soft palate near the uvula, with no inflammatory signs. A lesion biopsy was performed and histopathological diagnosis of diffuse proliferation of atypical lymphocytes and immunohistochemical study of non-Hodgkin, diffuse large-B cell, malignant lymphoma. The patient was then started treatment with chemotherapy.

Conclusion: Non-Hodgkin lymphoma appears as highly aggressive malignant lesions, and primary manifestation of the disease considered being rare in the oral cavity. Early diagnosis contributes significantly to a treatment more effectively.

Keywords: non-Hodgkin diffuse large B-cell lymphoma, oral manifestation, immunohistochemical.