Laryngeal Amyloidosis: A Case Report
Introduction: Laryngeal amyloidosis is a rare, usually benign process. It is defined by the presence of extracellular fibrillar proteins in a variety of organs and tissues. Amyloid deposition can be located without systemic involvement. The reason for the localized deposition is unknown, but there is a chance that deposits resulting from the synthesis amyloid protein site.
Objectives: Report a case of laryngeal amyloidosis located in arytenoid region, which will be addressed with diagnosis and treatment as well as the comparison between preoperative and postoperative, after 1 month of surgery.
Resumed report: A 50-year-old female patient complained of pharyngeal globus sensation, edema in the cervical region, dysphonia and progressive dysphagia since 1 year. She also had hoarse voice pattern and rough, due to which she had denied vocal effort, alcoholism, and previous weight loss. On undergoing videolaryngoscopy, a nodular lesion with regular contours and smooth, about 12 mm, yellowish in the right arytenoid was observed.
Conclusion: Laryngeal amyloidosis is rare, accounting for less than 1% of laryngeal tumors, however, should always be examined in the differential diagnosis of laryngeal masses, since it is a disease indistinguishable from other benign lesions, in the clinical point of view. It requires an essential histopathological confirmation with Congo red staining, which is pathognomonic, as well as research for extralaryngeal manifestations. Treatment is most often surgical (excisional biopsy), recommending the clinical monitoring of the patient, since relapses may occur even later.
Keywords: amyloidosis, larynx, laryngeal diseases.