Association between Cortical Auditory Evoked Potentials and Cardiac Autonomic Modulation at Rest
Introduction: The literature has investigated the relationship between auditory stimuli and the cardiovascular system. The auditory processing and cardiovascular modulation are based on the central nervous system.
Objective: The study aimed to analyze the association between the components of cortical auditory-evoked potential (CAEP) and cardiac autonomic regulation during rest.
Materials and Methods: A total of 15 healthy male subjects aged between 18 and 35 years were analyzed. Before starting the CAEP examination, we recorded heart rate of the subject at rest for 10 minutes through the heart rate monitor (Polar RS800CX). N2 (N200) and P3 (P300) CAEP components were regarded as the objects of study. The following time domain indices of HRV were analyzed: SDNN, pNN50, and RMSSD. The normality of the distribution was determined by the Shapiro-Wilk test. To perform the correlation between variables, we used the Pearson correlation test for parametric distributions, and for nonparametric distributions, Spearman correlation test were applied. Values were considered significant at p < 0.05.
Results: Strong correlations were observed with statistical significance of the amplitude of N2 (left ear) component during the frequency protocol with pNN50, RMSSD, and SDNN indices. We also showed a strong correlation of the amplitude of the N2 component during the duration protocol on the right ear with the SDNN index.
Conclusion: There is an association between the N2 component and the global modulation of heart rate during rest.
Keywords: long latency auditory evoked potential (P300), hearing, heart rate.