The effect of physical activity in pregnancy on the lipid profiles of mother and newborn, including HDL proteome

Introduction: Physical activity during pregnancy is a major factor contributing to fetal growth and body composition. The effect of physical activity in pregnancy on lipid profiles of mothers and newborns have not been extensively investigated before. Based on other studies outside of pregnancy we postulate that newborns delivered by physically active women have a different lipid profile compared to inactive women. If this can be proven, results will be a key foundation for developing low cost intervention to ultimately improve later health of the offspring.

Methods: This prospective, observational pilot study followed 40 healthy pregnant women throughout their pregnancy. Depending on their physical activity women were assessed into two groups, a physically active and inactive group, of 20 women each. Women were allocated to these groups based on their pre-pregnancy exercise behaviour and early pregnancy physical activity, investigated with a short screening questionnaire and objectified with an accelerometer worn for one week in the first trimester. Blood samples were collected from the patients four times during pregnancy. Additional arterial and venous blood samples were collected from the umbilical cord after birth. Lipid profiles were determined by the following values: HDL proteome, phospholipids, triglycerides, free fatty acids, LDL and total cholesterol. Data was analysed using Excel and SPSS.

Results and conclusion: Study ends in May 2014 and results along with conclusion will be presented.