Indikationen für die Hypothermie – welche sind gesichert, welche bieten eine Option

Die normale Körpertemperatur ist sehr genau geregelt, da sie zur normalen Funktion der zellulären Prozesse nötig ist. In einer Kohortenuntersuchung lag die mittlere rektale Temperatur als Surrogat für die zentrale Körpertemperatur bei 37,0 °C (95 %-Konfidenzintervall 36,7 – 37,5 °C) [1]. Davon zu unterscheiden ist die Hypothermie ein Zustand erniedrigter Körpertemperatur in einem homoiothermen Organismus.

• Literatur

• 1 Sund-Levander M, Forsberg C, Wahren LK. Normal oral, rectal, tympanic and axillary body temperature in adult men and women: a systematic literature review. Scand J Caring Sci 2002; 16: 122-128
• 2 Safar P, Klain M, Tisherman S. Selective brain cooling after cardiac arrest. Crit Care Med 1996; 24: 911-914
• 3 Göritz S, Schelkle H. Die EKZ beim Erwachsenen. In: Lauterbach G, ed. Handbuch der Kardiotechnik. 3.. ed. Stuttgart: G. Fischer Verlag; 1996: 225-240
• 4 Ginsberg MD, Sternau LL, Globus MY et al. Therapeutic modulation of brain temperature: relevance to ischemic brain injury. Cerebrovasc Brain Metab Rev 1992; 4: 189-225
• 5 Busto R, Dietrich WD, Globus MY et al. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J CerebBlood Flow Metab 1987; 7: 729-738
• 6 Holzer M. Targeted temperature management for comatose survivors of cardiac arrest. N Engl J Med 2010; 363: 1256-1264
• 7 Deakin CD, Nolan JP, Soar J et al. European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support. Resuscitation 2010; 81: 1305-1352
• 8 Bernard SA, Gray TW, Buist MD et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002; 346: 557-563
• 9 The Hypothermia After Cardiac Arrest study group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346: 549-556
• 10 Arrich J, Holzer M, Havel C et al. Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev 2012; 9 CD004128
• 11 Nielsen N, Wetterslev J, Cronberg T et al. Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest. N Engl J Med 2013; 369: 2197-2206
• 12 Lopez-de-Sa E, Rey JR, Armada E et al. Hypothermia in comatose survivors from out-of-hospital cardiac arrest: pilot trial comparing 2 levels of target temperature. Circulation 2012; 126: 2826-2833
• 13 Jacobs SE, Berg M, Hunt R et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2013; 1 CD003311
• 14 Villar J, Slutsky AS. Effects of induced hypothermia in patients with septic adult respiratory distress syndrome. Resuscitation 1993; 26: 183-192
• 15 Jalan R, Olde Damink SW, Deutz NE et al. Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension. Gastroenterology 2004; 127: 1338-1346
• 16 Oddo M, Schaller MD, Feihl F et al. From evidence to clinical practice: effective implementation of therapeutic hypothermia to improve patient outcome after cardiac arrest. Crit Care Med 2006; 34: 1865-1873
• 17 Skulec R, Kovarnik T, Dostalova G et al. Induction of mild hypothermia in cardiac arrest survivors presenting with cardiogenic shock syndrome. Acta Anaesthesiol Scand 2008; 52: 188-194
• 18 Schmidt-Schweda S, Ohler A, Post H et al. Moderate hypothermia for severe cardiogenic shock (COOL Shock Study I & II). Resuscitation 2013; 84: 319-325
• 19 O’Neill WW. for the COOL-MI study group. A prospective randomized trial of mild systemic hypothermia during PCI treatment of ST elevation myocardial infarction. 15th Annual Transcatheter Cardiovascular Therapeutics 2003
• 20 Grines CL. for the ICE-IT study group. Intravascular cooling adjunctive to primary coronary intervention for myocardial infarction. 16th Annual Transcatheter Cardiovascular Therapeutics 2004
• 21 Erlinge D, Gotberg M, Lang I et al. Rapid endovascular catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction. The CHILL-MI trial: a randomized controlled study of the use of central venous catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction. J Am Coll Cardiol 2014; 63: 1857-1865
• 22 Gotberg M, Olivecrona GK, Koul S et al. A pilot study of rapid cooling by cold saline and endovascular cooling before reperfusion in patients with ST-elevation myocardial infarction. Circ Cardiovasc Interv 2010; 3: 400-407
• 23 Crossley S, Reid J, McLatchie R et al. A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury. Crit Care 2014; 18: R75
• 24 Wan YH, Nie C, Wang HL et al. Therapeutic hypothermia (different depths, durations, and rewarming speeds) for acute ischemic stroke: a meta-analysis. J Stroke Cerebrovasc Dis 2014; 23: 2736-2747