Klinische Neurophysiologie 2014; 45(03): 168-175
DOI: 10.1055/s-0034-1387208
Originalia
© Georg Thieme Verlag KG Stuttgart · New York

Sonografische Methoden in der Hirntoddiagnostik

Ultrasound Methods in the Diagnosis of Brain Death
A. Günther
1   Hans-Berger-Klinik für Neurologie, Universitätsklinikum Jena
4   Integriertes Forschungs- und Behandlungszentrum (IFB) Sepsis und Sepsisfolgen (CSCC; Center for Sepsis Control & Care)
,
J. A. Llompart-Pou
2   Intensive Care Unit, Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spanien
,
C. Klingner
1   Hans-Berger-Klinik für Neurologie, Universitätsklinikum Jena
,
O. W. Witte
1   Hans-Berger-Klinik für Neurologie, Universitätsklinikum Jena
4   Integriertes Forschungs- und Behandlungszentrum (IFB) Sepsis und Sepsisfolgen (CSCC; Center for Sepsis Control & Care)
,
C. Terborg
3   Klinik für Neurologie, Asklepios-Klinik St. Georg, Hamburg
› Author Affiliations
Further Information

Publication History

Publication Date:
09 September 2014 (online)

Zusammenfassung

Die Hirntoddiagnostik ist eines der wichtigsten diagnostischen Verfahren in der Intensivmedizin. Nach Prüfung der Voraussetzungen und klinischer Feststellung von Koma und Hirnstammareflexie sind sonografische Methoden zum Nachweis der Irreversibilität von großer Bedeutung. Bei entsprechender Expertise ist die sonografische Diagnose des zerebralen Zirkulationsstillstandes mit hoher Sensitivität und Spezifität möglich, wenn intrakraniell in den Gefäßen des Circulus Willisii ein Pendelfluss oder systolische Spitzen in einem Abstand von 30 Minuten detektiert werden. Allerdings sollten limitierende Faktoren beachtet werden, die die Anwendung sonografischer Methoden in der Hirntoddiagnostik einschränken können.

Abstract

Brain death detection is one of the most important diagnostic procedures in intensive care medicine. If prerequisites and the clinical brain death syndrome are given, confirmatory tests e.g. sonographic methods are of high importance. Sonographic detection of cerebral circulatory arrest is possible with high sensitivity and specificity in skilled physicians, if oscillatory flow or systolic spikes are detected in the arteries of the Circle of Willis within a minimum 30 minute interval. However, limitations for the use of ultrasound methods in brain death detection must be considered.

 
  • Literatur

  • 1 A definition of irreversible coma. Report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death. JAMA 1968; 205: 337-340
  • 2 Shemie SD, Hornby L, Baker A et al. International guideline development for the determination of death. Intensive Care Med 2014; 40: 788-797
  • 3 Haupt WF, Rudolf J. European brain death codes: a comparison of national guidelines. J Neurol 1999; 246: 432-437
  • 4 Wijdicks EF. Brain death worldwide: accepted fact but no global consensus in diagnostic criteria. Neurology 2002; 58: 20-25
  • 5 Citerio G, Crippa IA, Bronco A et al. Variability in Brain Death Determination in Europe: Looking for a Solution. Neurocrit Care 2014; (Epub ahead of print)
  • 6 Wissenschaftlicher Beirat der Bundesärztekammer. Richtlinien zur Feststellung des Hirntodes. Dtsch Ärzteblatt 1998; 95: A1861-A1303
  • 7 Saposnik G, Basile VS, Young GB. Movements in brain death: a systematic review. Can J Neurol Sci 2009; 36: 154-160
  • 8 Young GB, Shemie SD, Doig CJ et al. Brief review: the role of ancillary tests in the neurological determination of death. Can J Anaesth 2006; 53: 620-627
  • 9 Lustbader D, O’Hara D, Wijdicks EF et al. Second brain death examination may negatively affect organ donation. Neurology 76: 119-124
  • 10 Tan WS, Wilbur AC, Jafar JJ et al. Brain death: use of dynamic CT and intravenous digital subtraction angiography. AJNR Am J Neuroradiol 1987; 8: 123-125
  • 11 Dupas B, Gayet-Delacroix M, Villers D et al. Diagnosis of brain death using two-phase spiral CT. AJNR Am J Neuroradiol 1998; 19: 641-647
  • 12 Escudero D, Otero J, Marques L et al. Diagnosing brain death by CT perfusion and multislice CT angiography. Neurocrit Care 2009; 11: 261-271
  • 13 Combes JC, Chomel A, Ricolfi F et al. Reliability of computed tomographic angiography in the diagnosis of brain death. Transplant Proc 2007; 39: 16-20
  • 14 Welschehold S, Boor S, Reuland K et al. Technical aids in the diagnosis of brain death: a comparison of SEP, AEP, EEG, TCD and CT angiography. Dtsch Arztebl Int 2012; 109: 624-630
  • 15 Sawicki M, Bohatyrewicz R, Safranow K et al. Computed tomographic angiography criteria in the diagnosis of brain death-comparison of sensitivity and interobserver reliability of different evaluation scales. Neuroradiology 2014; (Epub ahead of print)
  • 16 Ropper AH, Kehne SM, Wechsler L. Transcranial Doppler in brain death. Neurology 1987; 37: 1733-1735
  • 17 Hassler W, Steinmetz H, Pirschel J. Transcranial Doppler study of intracranial circulatory arrest. J Neurosurg 1989; 71: 195-201
  • 18 Steinmetz H, Hassler W. Reversible intracranial circulatory arrest in acute subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 1988; 51: 1355-1356
  • 19 Widder B, Görtler M. Doppler- und Duplexsonographie der hirnversorgenden Arterien: mit 29 Fallbeispielen und 87 Tabellen. Berlin: Springer; 2004
  • 20 Ducrocq X, Hassler W, Moritake K et al. Consensus opinion on diagnosis of cerebral circulatory arrest using Doppler-sonography: Task Force Group on cerebral death of the Neurosonology Research Group of the World Federation of Neurology. J Neurol Sci 1998; 159: 145-150
  • 21 Alexandrov AV, Sloan MA, Tegeler CH et al. Practice standards for transcranial Doppler (TCD) ultrasound. Part II. Clinical indications and expected outcomes. J Neuroimaging 2010; 22: 215-224
  • 22 de Freitas GR, Andre C. Sensitivity of transcranial Doppler for confirming brain death: a prospective study of 270 cases. Acta Neurol Scand 2006; 113: 426-432
  • 23 Monteiro LM, Bollen CW, van Huffelen AC et al. Transcranial Doppler ultrasonography to confirm brain death: a meta-analysis. Intensive Care Med 2006; 32: 1937-1944
  • 24 Young GB, Lee D. A critique of ancillary tests for brain death. Neurocrit Care 2004; 1: 499-508
  • 25 Ducrocq X, Braun M, Debouverie M et al. Brain death and transcranial Doppler: experience in 130 cases of brain dead patients. J Neurol Sci 1998; 160: 41-46
  • 26 Orban JC, El-Mahjoub A, Rami L et al. Transcranial Doppler shortens the time between clinical brain death and angiographic confirmation: a randomized trial. Transplantation 2012; 94: 585-588
  • 27 Karaali K, Cevikol C, Senol U et al. Orbital Doppler sonography findings in cases of brain death. AJNR Am J Neuroradiol 2000; 21: 945-947
  • 28 Dominguez-Roldan JM, Garcia-Alfaro C, Jimenez-Gonzalez PI et al. Brain death due to supratentorial masses: diagnosis using transcranial Doppler sonography. Transplant Proc 2004; 36: 2898-2900
  • 29 Lampl Y, Gilad R, Eschel Y et al. Diagnosing brain death using the transcranial Doppler with a transorbital approach. Arch Neurol 2002; 59: 58-60
  • 30 Conti A, Iacopino DG, Spada A et al. Transcranial Doppler ultrasonography in the assessment of cerebral circulation arrest: improving sensitivity by transcervical and transorbital carotid insonation and serial examinations. Neurocrit Care 2009; 10: 326-335
  • 31 Günther A, Axer H, Llompart-Pou J-A et al. Determination of Brain Death: An Overview with a Special Emphasis on New Ultrasound Techniques for Confirmatory Testing. The Open Critical Care Medicine Journal 2011; 4 35-43
  • 32 Thompson BB, Wendell LC, Potter NS et al. The Use of Transcranial Doppler Ultrasound in Confirming Brain Death in the Setting of Skull Defects and Extraventricular Drains. Neurocrit Care 2014; (Epub ahead of print)
  • 33 Llompart-Pou JA, Abadal JM, Velasco J et al. Contrast-enhanced transcranial color sonography in the diagnosis of cerebral circulatory arrest. Transplant Proc 2009; 41: 1466-1468
  • 34 Abadal JM, Llompart-Pou JA, Homar J et al. Ultrasonographic cerebral perfusion in assessment of brain death: a preliminary study. J Ultrasound Med 2008; 27: 791-794
  • 35 Seidel G, Meairs S. Ultrasound contrast agents in ischemic stroke. Cerebrovasc Dis 2009; 27 (Suppl. 02) 25-39
  • 36 Della Martina A, Meyer-Wiethe K, Allemann E et al. Ultrasound contrast agents for brain perfusion imaging and ischemic stroke therapy. J Neuroimaging 2005; 15: 217-232
  • 37 Meyer-Wiethe K, Cangur H, Schindler A et al. Ultrasound perfusion imaging: determination of thresholds for the identification of critically disturbed perfusion in acute ischemic stroke – a pilot study. Ultrasound Med Biol 2007; 33: 851-856
  • 38 Eyding J, Krogias C, Schollhammer M et al. Contrast-enhanced ultrasonic parametric perfusion imaging detects dysfunctional tissue at risk in acute MCA stroke. J Cereb Blood Flow Metab 2006; 26: 576-582
  • 39 Krogias C, Postert T, Meves S et al. Semiquantitative analysis of ultrasonic cerebral perfusion imaging. Ultrasound Med Biol 2005; 31: 1007-1012
  • 40 Braum M, Ducrocq X, Huot JC et al. Intravenous angiography in brain death: report of 140 patients. Neuroradiology 1997; 39: 400-405
  • 41 Bertagna F, Barozzi O, Puta E et al. Residual brain viability, evaluated by (99m)Tc-ECD SPECT, in patients with suspected brain death and with confounding clinical factors. Nucl Med Commun 2009; 30: 815-821
  • 42 Spieth ME, Ansari AN, Kawada TK et al. Direct comparison of Tc-99m DTPA and Tc-99m HMPAO for evaluating brain death. Clin Nucl Med 1994; 19: 867-872