Semin Neurol 2014; 34(03): 293-305
DOI: 10.1055/s-0034-1386767
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Hereditary Spastic Paraplegia: Clinical Principles and Genetic Advances

John K. Fink
1  Department of Neurology, University of Michigan; Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan
› Author Affiliations
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Publication History

Publication Date:
05 September 2014 (online)


Hereditary spastic paraplegia (HSP) refers to inherited disorders in which spastic gait is either the only feature or is a major syndrome feature. There are more than 70 genetic types of HSP. Neuropathological studies, albeit limited to only a few genetic types of HSP, have identified axon degeneration involving the distal ends of the corticospinal tracts and fasciculus gracilis fibers. In this review, the author highlights the clinical and genetic features of HSP.