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Planta Med 2014; 80(18): 1746-1752
DOI: 10.1055/s-0034-1383305
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

β-Carboline Alkaloids from Galianthe ramosa Inhibit Malate Synthase from Paracoccidioides spp.

Carla S. de Freitas
1   Instituto de Química – Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Lucilia Kato
1   Instituto de Química – Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Cecília M. A. de Oliveira
1   Instituto de Química – Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Luiz H. K. Queiroz jr.
1   Instituto de Química – Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Mábio J. Santana
1   Instituto de Química – Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Ivânia T. Schuquel
2   Depto. Química, Universidade Estadual de Maringá, Maringá, PR, Brazil
,
Piero G. Delprete
3   Herbier de Guyane, IRD, UMR AMAP, Cayenne, French Guiana, France
,
Roosevelt A. da Silva
4   Núcleo Colaborativo de BioSistemas, Campus Jataí, Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Guilherme O. Quintino
4   Núcleo Colaborativo de BioSistemas, Campus Jataí, Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Benedito R. da Silva Neto
5   Instituto de Ciências Biológicas – Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Célia M. A. Soares
5   Instituto de Ciências Biológicas – Universidade Federal de Goiás, Goiânia, GO, Brazil
,
Maristela Pereira
5   Instituto de Ciências Biológicas – Universidade Federal de Goiás, Goiânia, GO, Brazil
› Author Affiliations
Further Information

Publication History

received 06 September 2013
revised 01 October 2014

accepted 12 October 2014

Publication Date:
20 November 2014 (online)

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Abstract

As part of our continuing chemical and biological analyses of Rubiaceae species from Cerrado, we isolated novel alkaloids 1 and 2, along with known compounds epicatechin, ursolic acid, and oleanolic acid, from Galianthe ramosa. Alkaloid 2 inhibited malate synthase from the pathogenic fungus Paracoccidioides spp. This enzyme is considered an important molecular target because it is not found in humans. Molecular docking simulations were used to describe the interactions between the alkaloids and malate synthase.

Key words

Galianthe ramosa - Rubiaceae - indole alkaloids - malate synthase - Paracoccidioides spp.

Supporting Information

 

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