Planta Med 2014; 80(13): 1113-1117
DOI: 10.1055/s-0034-1382956
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Isolation and Cytotoxic Effect of Anthraquinones from Morinda umbellata

Chun-Tang Chiou
1   National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan
,
Ruie-Yu Hsu
2   Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan
,
Lie-Chwen Lin
1   National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan
› Author Affiliations
Further Information

Publication History

received 29 January 2014
revised 03 July 2014

accepted 09 July 2014

Publication Date:
19 August 2014 (online)

Abstract

Four new anthraquinones, 1,6-dihydroxy-2-methoxymethylanthraquinone (1), 6-hydroxy-7-methoxy-2-methoxymethylanthraquinone (3), 3,6-dihydroxy-7-methoxy-2-methylanthraquinone (4), and 6-hydroxy-2-methoxymethylanthraquinone (8), together with 12 known anthraquinones and 6 other known compounds, were isolated from the EtOAc extract of Morinda umbellata. Among the isolated compounds, 1, rubiadin (14), and, 3-hydroxy-2-hydroxymethylanthraquinone (16) exhibited significant cytotoxicities against HepG2 cells, with GI50 values of 4.4, 3.6, and 4.8 µM, respectively.

Supporting Information