Planta Med 2014; 80 - PP25
DOI: 10.1055/s-0034-1382720

Hypoglycemic properties of preparations and compounds from Artemisia ludoviciana Nutt.

G Anaya-Eugenio 1, I Rivero-Cruz 1, J Rivera-Chávez 1, R Mata 1
  • 1Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, México

Artemisia ludoviciana (Asteraceae) is used in contemporary Mexico for the treatment of diabetes. Therefore, in this work the hypoglycemic and/or antihyperglycemic activities of several preparations (31.6 –316 mg/kg) and compounds (5.6 – 31.6 mg/kg) from the plant were established using well-known animal models. An infusion (AE), an organic extract (OE) as well as the essential oil (EO), prepared by conventional procedures, showed noted hypoglycemic effect in normal and diabetic mice (NA 50 mg/kg, STZ 120 mg/kg). The relevant hypoglycemic components of the infusion were eupatilin (1) and arglanin (3). This effect was experimentally related with the regulation of insulin release. On the other hand, 4 could be responsible of the antihyperglycemic action since it inhibited the activity of yeast α-glucosidase (IC50= 1.65 mM). Kinetic analysis revealed a mixed-type of inhibition.

Fig. 1