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Antioxidant and hypolipidemic activity of Mucuna pruriens L. (DC) seed extract
Mucuna pruriens L. (DC) an annual climbing legume belonging to the family Leguminoceae, has been used for the management of male infertility, nervous disorders and also as an aphrodisiac. Antioxidant activity of aqueous extract of M. pruriens seed was studied for its free radical scavenging property on different in vitro models. e.g. 1,1-diphenyl -2-picryl hydrazyl (DPPH), nitric oxide and lipid peroxide models. The extract showed good dose dependent free radical scavenging property in all models. Hyperlipidemia in rats was induced by giving high cholesterol diet for seven days in standard rat chow diet. Rats fed with high cholesterol diet showed significant increase in serum triglyceride, cholesterol, VLDL, LDL and decrease HDL-C levels. Treatment with M. pruriens at a dose of 200 mg/kg and 400 mg/kg produced dose dependant decrease in serum triglyceride, cholesterol, VLDL, LDL and increase in HDL-C. The HDL/total cholesterol ratio and atherogenic index was also found to be decrease significantly in seed extract treated group. The extract produced significant decrease in lipid peroxidation, which was found to be increased in high cholesterol diet rats. In, conclusion, our data suggests significant lipid lowering effect of M. pruriens associated with its antioxidant potential due to presence of L-dopa in the extract.