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DOI: 10.1055/s-0034-1382700
Studies on anti-arthritic activity of Vatari guggul (a traditional formulation of indian system of medicine ayurveda) in rats
Ethanol extract of Vatari Guggulu (EVG) was tested for its anti-arthritic activity in formaldehyde and Complete Freund's Adjuvant (CFA) induced arthritic rat model.
Materials and Methods: Arthritis was induced by administration of formaldehyde (2%v/v) or CFA into the sub-plantar surface of the left hind paw of the animal. Joint swelling was measured in formaldehyde induced arthritis. Paw volume, paw thickness, body weight, blood parameters and histo-pathological parameters were determined in CFA induced arthritis.
Result and Discussion: In arthritic conditions, there was joint swelling, decreased levels of hemoglobin and RBC, increase in the Rheumatoid Factor, WBC, platelet count and ESR which reflected anemia, stimulation of immune system and chronic nature of the disease. There was also an increase in the triglycerides and cholesterol as a result of arthritis. Treatment with various doses of the EVG brought these changes to near normal levels in treatment groups in a dose dependent manner.
Conclusion: All the above changes associated with formaldehyde and CFA were brought back to almost normal level by test formulation might be due to combined activity of phyto-constituents present in it.